Abstract: Tissue engineering structures with biologically favorable structural and chemical properties are disclosed. More particularly, the present disclosure is directed to tissue engineered structures having a cryogel scaffold and honey. The tissue engineered structures having a cryogel scaffold and honey can further include at least one biomolecule. The tissue engineered structures can be used to promote cellular chemotaxis, enhance cell proliferation, enhance extracellular matrix production, increase angiogenesis, and provide antimicrobial activity. The nature of the tissue engineered structures provides a template for cellular infiltration and guide tissue regeneration. The tissue engineered structures can be used in the treatment of dermal wounds (burns, chronic wounds, etc.) or as a tissue engineering scaffold in a wide range of applications.

Abstract: Disclosed are silk fibroin cryogels and methods for preparing silk fibroin cryogels. The silk fibroin cryogels can be used to promote cellular chemotaxis, enhance cell proliferation, enhance extracellular matrix production, promote calcified matrix production, and increase angiogenesis. The silk fibroin cryogels can further be used in the treatment of dermal wounds (burns, chronic wounds, etc.), bone tissue engineering and oral and maxillofacial repair.