Patents by Inventor Katherine S. Takaki

Katherine S. Takaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzoxazole derivatives as novel melatonergic agents
    Patent number: 6737431
    Abstract: Novel benzoxazole derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: May 18, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Katherine S. Takaki, Li-Qiang Sun, Graham Johnson, Stephen R. Bertenshaw, Derek Denhart, Jie Chen
  • Benzoxazole derivatives as novel melatonergic agents
    Publication number: 20030216456
    Abstract: Novel benzoxazole derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.
    Type: Application
    Filed: March 6, 2003
    Publication date: November 20, 2003
    Inventors: Katherine S. Takaki, Li-Qiang Sun, Graham Johnson, Stephen R. Bertenshaw, Derek Denhart, Jie Chen
  • Arylalkylbenzofuran derivatives as melatonergic agents
    Patent number: 6569894
    Abstract: Novel benzofuran and dihydrobenzofuran derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: May 27, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Katherine S. Takaki, Li-Quang Sun, Graham Johnson, James R. Epperson, Stephen R. Bertenshaw
  • Heterocyclic cis cyclopropane derivatives as melatonergic agents
    Patent number: 6214869
    Abstract: There is provided a novel series of cis cyclopropane compounds of Formula I wherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: April 10, 2001
    Assignee: Bristol-Myers Squibb
    Inventors: Jie Chen, Pierre Dextraze, Marco Dodier, Katherine S. Takaki
  • Heterocyclic aminopyrrolidine derivatives as melatonergic agents
    Patent number: 6211225
    Abstract: There is provided a novel series of heterocyclic aminopyrrolidine compounds of Formula I wherein R1, R2, R3, R4, W, Z and the wavy bond are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: April 3, 2001
    Assignee: Bristol-Meyers Squibb
    Inventors: Katherine S. Takaki, Guanglin Luo, Stephen R. Bertenshaw
  • Benzopyran derivatives as melatonergic agents
    Patent number: 6060506
    Abstract: Novel derivatives of benzopyran are provided which are useful as melatonergic agents.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: May 9, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. Catt, Graham Johnson, Daniel J. Keavy, Ronald J. Mattson, Michael F. Parker, Katherine S. Takaki, Joseph P. Yevich
  • Spirocyclopropyl fluorenes as melatonergic agents
    Patent number: 6028112
    Abstract: There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R.sup.1 and X are as defined herein which are useful as melatonergic agents.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: February 22, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Karen L. Leboulluec, Katherine S. Takaki
  • Benzodioxa alkylene ethers as melatonergic agents
    Patent number: 5981571
    Abstract: Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: November 9, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. Catt, Graham Johnson, Daniel J. Keavy, Ronald J. Mattson, Michael F. Parker, Katherine S. Takaki, Joseph P. Yevich
  • Polycyclic ethyl alkylamide melatonergic agents
    Patent number: 5948817
    Abstract: Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH.sub.2).sub.n, wherein n is 1-4;X=O, CH.sub.2, or CH (when a double bond is present);R=C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, or C.sub.1-3 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-4 alkoxyalkyl, C.sub.1-4 trifluoromethylalkyl, C.sub.1-6 aminoalkyl; andY=H, C.sub.1-6 alkoxy or halogen.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: September 7, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: James Epperson, Graham Johnson, Daniel J. Keavy, Katherine S. Takaki
  • Anticonvulsant pyridinyl benzamide derivatives
    Patent number: 5859033
    Abstract: A series of pyridinyl tri-substituted benzamide derivatives of general structure ##STR1## wherein the symbols R.sup.1, R.sup.2, X and n are described in detail in the specification, are useful as anticonvulsants agents.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: January 12, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Katherine S. Takaki, Astrid Ortiz, Brett T. Watson
  • Benzofuran and dihydrobenzofuran melatonergic agents
    Patent number: 5856529
    Abstract: Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: January 5, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. Catt, Graham Johnson, Daniel J. Keavy, Ronald J. Mattson, Michael F. Parker, Katherine S. Takaki, Joseph P. Yevich
  • Ethylamido fluorenes and improved method of making same
    Patent number: 5736578
    Abstract: Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ;Z=C.sub.1-6 alkyl; --(CH.sub.2).sub.m --CF.sub.3 (m=0-2); CD.sub.3 ; or ##STR2## n=1 or 2; and R=C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.2-4 alkenyl, halogen substituted C.sub.1-6 alkyl, or C.sub.1-6 alkoxy substituted C.sub.1-6 alkyl.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: April 7, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Brett T. Watson, Katherine S. Takaki, Joseph P. Yevich, James R. Epperson, George N. Karageorge, Karen L. Leboulluec
  • Ethylamino carbazole melatonergic agents
    Patent number: 5677328
    Abstract: Novel substituted carbazole compounds of Formula I are active as melatonergic agents: ##STR1## wherein: R.sub.1 is C(O)R.sub.3 or SO.sub.2 R.sub.4 ;R.sub.2 is H or C.sub.1-6 alkoxy;R.sub.3 is C.sub.1-6 alkyl, (CH.sub.2).sub.n SR.sub.4, (CH.sub.2).sub.n OR.sub.4, (CH.sub.2).sub.n SO.sub.2 R.sub.4, or NHR.sub.4 ;R.sub.4 is C.sub.1-4 alkyl; andm is 1 or 2; andn is 1 to 4.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: October 14, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Katherine S. Takaki, Marc A. Bruce, Graham S. Poindexter, Brett T. Watson, Joseph P. Yevich
  • Melatonergic agents
    Patent number: 5661185
    Abstract: New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R.sub.1 =C.sub.1-3 alkyl, allyl, C.sub.3-6 cycloalkyl substituted C.sub.1-4 alkyl;R.sub.2 =hydrogen, halogen or C.sub.1-4 alkoxy;R.sub.3 =hydrogen or C.sub.1-4 alkyl;R.sub.4 =C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted amino, carboxylic acid substitutedC.sub.1-4 alkyl or C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl, or straight or branched chainC.sub.2-4 alkenyl;A=a linear C.sub.2-4 alkanediyl or alkenediyl chain, provided that A not be --CH.sub.2 CH.sub.2 -- when X is a bond; andX=a covalent bond or oxygen.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: August 26, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Katherine S. Takaki, George N. Karageorge, Daniel J. Keavy, Michael F. Parker, Brett T. Watson
  • Tetralinyl-and indanyl-ethylamides
    Patent number: 5661186
    Abstract: Certain tetralinyl- and indanyl-ethylamides are useful central nervous system agents.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: August 26, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Katherine S. Takaki, Brett T. Watson, Graham S. Poindexter, James R. Epperson
  • Melatonergic agents
    Patent number: 5541228
    Abstract: New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R.sub.1 =C.sub.1-3 alkyl, allyl, C.sub.3-6 cycloalkyl substituted C.sub.1-4 alkyl;R.sub.2 =hydrogen, halogen or C.sub.1-4 alkoxy;R.sub.3 =hydrogen or C.sub.1-4 alkyl;R.sub.4 =C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted amino, carboxylic acid substitutedC.sub.1-4 alkyl or C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl, or straight or branched chain C.sub.2-4 alkenyl;A=a linear C.sub.2-4 alkanediyl or alkenediyl chain, provided that A not be --CH.sub.2 CH.sub.2 -- when X is a bond; andX=a covalent bond or oxygen.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: July 30, 1996
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Katherine S, Takaki, George N. Karageorge, Daniel J. Keavy, Michael F. Parker, Brett T. Watson
  • Naphthothiophenimines for treating neuronal disorders caused by ischemia
    Patent number: 5064831
    Abstract: Naphthothiophenimines of formula I ##STR1## wherein R.sup.1 is, inter alia, alkyl, cycloaklyl, alkenyl, phenalkyl or aminoalkyl.Formula I compounds are useful in treating brain ischemia and resulting disorders.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: November 12, 1991
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Katherine S. Takaki