Abstract: A method of treating an RNA virus infection in a subject in need that includes administering a therapeutically effective amount of a heparanase inhibitor. The RNA virus includes SARS-CoV-1, SARS-CoV-2, HTLV-1, HIV-1, and any combination thereof. The heparanase inhibitor includes heparin, a heparin mimetic, or any combination thereof. In some aspects, the heparanase inhibitor is Roneparstat. In some aspects, the administration of the therapeutically effective amount of the heparanase inhibitor results in the inhibition of infection by the RNA virus and associated inflammatory cytokine production.

Abstract: The invention encompasses methods of inhibiting bone loss and bone metastasis.

Abstract: Disclosed are methods for treating, preventing or inhibiting tumor cell metastasis, tumor cell formation, and destroying tumors in a subject comprising administering to the subject in need of such therapy a therapeutically effective amount of an activated aIIb?3 receptor antagonist and by transplanting affected bone marrow with ?3?/?marrow or controlling the expression of ?3 integrin in vitro or in vivo. The activated allb?3 receptor antagonist is preferably a spiro compound.