Abstract: An on-body insertion system is described. The on-body system includes a sensor in a first position being substantially parallel to an insertion surface. Activation of an actuator transitions the sensor to a second position. Wherein the transition imparts movement to the sensor that is substantially parallel to the insertion surface and the second position results in the sensing area being beneath the insertion surface.

Abstract: In one embodiment an insertion assembly to implant a sensor is disclosed. The insertion device includes an encasement with an interior defined between an encasement top and an encasement bottom. The assembly further includes a slider with a slider top and a slider bottom face. The slider top is located within the interior of encasement and the slider initially is in a first position, capable of transitioning to a second position and further capable of transitioning to a third position. Wherein in the first position the slide bottom face is coincident with the encasement bottom, in the second position the slide bottom face is fully contained in the interior, and in the third position, the slide bottom face extends beyond the encasement bottom by a gap.

Abstract: An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

Abstract: In one embodiment, an integrated cannula and sensor assembly is disclosed. The integrated cannula and sensor assembly includes a cannula with a proximal end and a distal end. The cannula also has a body and a tip. The body includes a channel and a body distal that is defined between the proximal end and the distal end. The tip is defined between the body distal and the distal end. The assembly further includes a sensor assembly that is located within the channel, wherein the tip further includes an undercut configured to retain the sensor assembly.

Abstract: An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

Abstract: In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.

Abstract: A multi-analyte sensor system is disclosed that includes a sensor probe with a first set of electrodes that transduce choline into electrical signals and a second set of electrodes that transduce tissue oxygen into electrical signals. The sensor probe includes a third set of electrodes that provide working and counter electrode functionality for the first and second set of electrodes. The system also has an electronics module interfaced with the sensor probe that includes a transceiver to transmit sensor data. The system further includes control circuitry that determines a choline state based on the first set of electrodes and determines a tissue oxygen state based on the second set of electrodes. The control circuitry is also configured to initiate an alarm condition based on one or more signals from the first and second set of electrodes.

Abstract: In one embodiment, an analyte sensor is disclosed. The analyte sensor includes a working conductor having an electrode reactive surface. The analyte sensor further includes a first reactive chemistry being responsive to a first analyte and a first transport matrix that includes a first transport material and a mitigation compound. The first transport material enables flux of the first analyte to the first reactive chemistry. The analyte sensor includes a second transport material disposed over and configured to enable transport of a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially overlapping a portion of the electrode reactive surface.

Abstract: A multi-analyte sensor system is disclosed. The system includes a sensor probe that has a first set of electrodes that transduce glucose into electrical signals, a second set of electrodes that transduce lactate into electrical signals and a third set of electrodes that provide working and counter electrode functionality for the first and second set of electrodes. The system has an electronics module that electrically interfaces with the sensor probe, and includes a transceiver configured to transmit sensor data. The system also includes control circuitry communicatively coupled to the electronics module that determines a glucose state based on signals from the first set of electrodes and also determine a lactate state based on signals from the second set of electrodes. The control circuitry also generates an insulin infusion pump control signal based on signals from the first and second set of electrodes.

Abstract: Sensing and infusion devices are described. In one embodiment, a sensing and infusion device may include an implantable segment having a sensor. The sensing and infusion device may also include a catheter, and a sensor channel may be formed in the catheter. The sensor channel may be configured to retain at least a portion of the implantable segment.

Abstract: In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.

Abstract: In one embodiment, a working electrode to detect the presence of an analyte is disclosed. The working electrode includes an electrical insulator having a well. The working further includes an electrical conductor that is positioned at the bottom of the well and a reactive chemistry that includes a dehydrogenase based enzyme and cofactor at least partially filling the well. Where the reactive chemistry has a minimum molecular weight and a hydrogel is located over the reactive chemistry. The hydrogel is in contact with the insulation and the reactive chemistry and the hydrogel has a porosity less than the minimum molecular weight of the reactive chemistry.

Abstract: Sensing and infusion devices are described. In one embodiment, a sensing and infusion device may include an implantable segment having a sensor. The sensing and infusion device may also include a catheter, and a sensor channel may be formed in the catheter. The sensor channel may be configured to retain at least a portion of the implantable segment.

Abstract: A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Abstract: A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Abstract: In one embodiment a system to monitor an analyte and dispense an infusate is disclosed. The system includes an on-body assembly with a first piece and a second piece. The first piece contains a sensor and a cannula and the cannula is in fluid communication with a first piece fluid channel. The second piece contains a pump mechanism connected to a second piece fluid channel. When the first piece is coupled to the second piece, the first piece fluid channel is placed in fluid communication with the second piece fluid channel to establish fluid transport from the pump mechanism through the cannula.

Abstract: In one embodiment, an insertion assembly is disclosed that includes an electronics assembly. The electronics assembly includes a base and a housing and the housing has an enclosed portion and a mating portion. The insertion assembly further includes a sensor assembly that is detached from the electronics assembly. The sensor assembly includes a sensor and at least one mating feature. The sensor assembly is detachably coupled to a slider in a first position. The slider is coupled to an energy storage system. When the slider transitions to a second position, the sensor assembly is coupled to the electronics assembly to define an on-body assembly. The transition to the second position loads the energy storage system and upon actuation, the energy storage system is unloaded to transition the slider to the first position and the on-body assembly is positioned to decouple from the slider.

Abstract: A system to automatically detect at least one physiological state is disclosed. The system includes a single probe for insertion within a subject that has an analyte sensor array for continuous monitoring of at least glucose and a second analyte. The system further includes an electronics module that includes a power supply, a processor, memory and a bi-directional communications module. When the electronics module is coupled with the analyte sensor array the power supply delivers power to the analyte sensor array and the processor. The processor analyzing glucose and the second analyte data to detect a first physiological state from a plurality of physiological states.

Abstract: A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Abstract: In one embodiment, a sensor assembly is disclosed. The sensor assembly includes a first analyte sensor being formed on a first substrate and a second analyte sensor being formed on a second substrate. Wherein the first analyte sensor is coupled to the second analyte sensor within a coupling area defined by an overlap between the first analyte sensor and the second analyte sensor.