Patents by Inventor Kathleen Clarkson
Kathleen Clarkson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170183691Abstract: A conversion process provides using different co-cultured cell lines to express different sets of enzymes catalyzing the same process. For example, in a Simultaneous Saccharification and Co-Fermentation (SSCF) process, a starch substrate is converted to alcohol by contacting the substrate with yeast and Aspergillus niger cells. Because A. niger expresses an endogenous glucoamylase and alpha-amylase, these enzymes do not need to be added during the SSCF process.Type: ApplicationFiled: April 6, 2015Publication date: June 29, 2017Applicant: Danisco US Inc.Inventors: Kathleen A. Clarkson, Matthew T. Reboli, Jacquelyn A. Huitink, Paula Johanna Maria Teunissen, Gopal K. Chotani, Jayarama K. Shetty
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Patent number: 9365871Abstract: A fungal ?-amylase is provided from Aspergillus clavatus (AcAmy1). AcAmy1 has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the ?-amylase or glucoamylase. AcAmy1 also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an ?-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example.Type: GrantFiled: December 4, 2014Date of Patent: June 14, 2016Assignee: Danisco US Inc.Inventors: Jing Ge, Ling Hua, Martijn Silvan Scheffers, Zhongmei Tang, Marco Van Brussel-Zwijnen, Casper Vroemen, Bo Zhang, Kathleen A. Clarkson, Jacquelyn A. Huitink, Paula Johanna Maria Teunissen
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Publication number: 20150152442Abstract: A fungal ?-amylase is provided from Aspergillus clavatus (AcAmy1). AcAmy1 has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the ?-amylase or glucoamylase. AcAmy1 also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an ?-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example.Type: ApplicationFiled: December 4, 2014Publication date: June 4, 2015Inventors: Jing Ge, Ling Hua, Martijn Silvan Scheffers, Zhongmei Tang, Marco Van Brussel-Zwijnen, Casper Vroemen, Bo Zhang, Kathleen A. Clarkson, Jacquelyn A. Huitink, Paula Johanna Maria Teunissen
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Publication number: 20150147786Abstract: A process for mechanical destructuring of starch-based biomass was developed that makes use of a short application of high compression, impact, and shearing forces. The biomass may be destructured using a specific energy input that is less than 40% of the total combustible energy of the biomass. The destructured starch-based biomass, with or without saccharification and/or in-feed glycosyl hydrolase enzymes, may be used in feed applications. The destructured starch-based may saccharified to produce syrups and fermentable sugars, and for production of products including ethanol using a biocatalyst.Type: ApplicationFiled: November 18, 2014Publication date: May 28, 2015Inventors: KATHLEEN A CLARKSON, F Glenn Gallagher, Aaron Perelman, Luis Fernando Romero Millan, Vivek Sharma, Jayarama K. Shetty, Daniel A. Slanac, Paula Johanna Maria Teunissen
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Patent number: 8945889Abstract: A fungal ?-amylase is provided from Aspergillus clavatus (AcAmyl). AcAmyl has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the ?-amylase or glucoamylase. AcAmyl also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an ?-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example.Type: GrantFiled: May 6, 2013Date of Patent: February 3, 2015Assignee: Danisco US Inc.Inventors: Jing Ge, Ling Hua, Martijn Silvan Scheffers, Zhongmei Tang, Marco Van Brussel-Zwijnen, Casper Vroemen, Bo Zhang, Kathleen A. Clarkson, Jacquelyn A. Huitink, Paula Johanna Maria Teunissen
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Publication number: 20150030679Abstract: A stable, durable granule for feed compositions has a core, at least one active agent; and at least one coating. The active agent of the granule retains at least 50% activity, at least 60% activity, at least 70% activity, at least 80% activity after conditions selected from one or more of a) a feed pelleting process, b) a steam-heated feed pretreatment process, c) storage, d) storage as an ingredient in an unpelleted mixture, and e) storage as an ingredient in a feed base mix or a feed premix comprising at least one compound selected from trace minerals, organic acids, reducing sugars, vitamins, choline chloride, and compounds which result in an acidic or a basic feed base mix or feed premix.Type: ApplicationFiled: July 23, 2014Publication date: January 29, 2015Applicant: DANISCO US INC.Inventors: Nathaniel T. BECKER, Kathleen A. CLARKSON, Douglas A. DALE, Beth FRYKSDALE, Mark S. GEBERT, Troels N. GRAVESEN, Michael PARTSUF
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Publication number: 20140127757Abstract: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.Type: ApplicationFiled: October 30, 2013Publication date: May 8, 2014Applicant: Danisco US Inc.Inventors: Toby M. Baldwin, Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz
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Patent number: 8715647Abstract: The use is provided composition as a feed additive which comprises one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EGIII and any functionally active derivative of any thereof. Such endoglucanases may be obtained from a genetically modified strain of the fungus Trichoderma. Also provided is an enzyme-based feed additive which comprises EGI and/or EGII which lack the cellulose binding domain, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. A further enzyme-based feed additive is provided which comprises a cereal-based carrier, one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase.Type: GrantFiled: August 5, 2005Date of Patent: May 6, 2014Assignee: Danisco US Inc.Inventors: Michael R. Bedford, Andrew J. Morgan, Timothy Fowler, Kathleen A. Clarkson, Michael Ward, Katherine D. Collier, Edmund A. Larenas
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Publication number: 20130323798Abstract: A fungal ?-amylase is provided from Aspergillus clavatus (AcAmyl). AcAmyl has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the ?-amylase or glucoamylase. AcAmyl also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an ?-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example.Type: ApplicationFiled: May 6, 2013Publication date: December 5, 2013Applicant: Danisco US Inc.Inventors: Jing Ge, Ling Hua, Martijn Silvan Scheffers, Zhongmei Tang, Marco Van Brussel-Zwijnen, Casper Vroemen, Bo Zhang, Kathleen A. Clarkson, Jacquelyn A. Huitink, Paula Johanna Maria Teunissen
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Publication number: 20120309664Abstract: The present invention generally relates to particulate compositions and methods for making the compositions. It specifically relates to improved spray drying methods that substantially reduce the production of small particles that pose industrial hygiene concerns for factory workers and product consumers. In a composition aspect, the present invention provides an atomized aqueous composition. The composition is formed using a spray-drying apparatus. It includes 0.001 to 0.10 weight percent of a polymer, which is selected from a group consisting of a cellulose-based polymer, a gum, and a synthetic polymer. It further includes at least one polypeptide, which is present in the aqueous composition at a concentration greater than 0.01 weight percent.Type: ApplicationFiled: June 7, 2012Publication date: December 6, 2012Applicant: Danisco US Inc.Inventors: Herbert B. Scher, Deborah S. Winetzky, Nathaniel T. Becker, Kathleen A. Clarkson, Mark S. Gebert, Troels N. Gravesen, Michael Partsuf
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Patent number: 8288517Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.Type: GrantFiled: April 6, 2012Date of Patent: October 16, 2012Assignee: Danisco US Inc.Inventors: Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz, Craig E. Pilgrim, Piet van Solingen, Michael Ward
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Publication number: 20120225469Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.Type: ApplicationFiled: April 6, 2012Publication date: September 6, 2012Applicant: Danisco US Inc.Inventors: Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz, Craig E. Pilgrim, Piet van Solingen, Michael Ward
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Patent number: 8173409Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.Type: GrantFiled: October 20, 2009Date of Patent: May 8, 2012Assignee: Danisco US Inc.Inventors: Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz, Craig E. Pilgrim, Piet Van Solingen, Michael Ward
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Publication number: 20100190208Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.Type: ApplicationFiled: October 20, 2009Publication date: July 29, 2010Inventors: Kathleen A. CLARKSON, Nigel DUNN-COLEMAN, Suzanne E. LANTZ, Craig E. PILGRIM, Piet VAN SOLINGEN, Michael Ward
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Publication number: 20100124586Abstract: A stable, durable granule for feed compositions has a core, at least one active agent; and at least one coating. The active agent of the granule retains at least 50% activity, at least 60% activity, at least 70% activity, at least 80% activity after conditions selected from one or more of a) a feed pelleting process, b) a steam-heated feed pretreatment process, c) storage, d) storage as an ingredient in an unpelleted mixture, and e) storage as an ingredient in a feed base mix or a feed premix comprising at least one compound selected from trace minerals, organic acids, reducing sugars, vitamins, choline chloride, and compounds which result in an acidic or a basic feed base mix or feed premix.Type: ApplicationFiled: October 12, 2006Publication date: May 20, 2010Applicant: GENENCOR INTERNATIONAL, INC.Inventors: Nathaniel T. Becker, Kathleen A. Clarkson, Douglas A. Dale, Beth Fryksdale, Mark S. Gebert, Michael Partsuf, Troels N. Gravesen
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Publication number: 20100062511Abstract: The invention is directed to modified xylanases having increased stability in harsh industrial environments, such as increased pH and/or temperature.Type: ApplicationFiled: March 17, 2009Publication date: March 11, 2010Applicant: DANISCO US INC., GENENCOR DIVISIONInventors: Kathleen A. Clarkson, Fred Fenel
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Patent number: 7629451Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.Type: GrantFiled: July 2, 2008Date of Patent: December 8, 2009Assignee: Genencor International, Inc.Inventors: Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz, Craig E. Pilgrim, Piet Van Solingen, Michael Ward
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Publication number: 20090203088Abstract: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.Type: ApplicationFiled: January 21, 2009Publication date: August 13, 2009Applicant: Genencor International, Inc.Inventors: Toby M. Baldwin, Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz
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Publication number: 20090061483Abstract: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases.Type: ApplicationFiled: July 2, 2008Publication date: March 5, 2009Inventors: Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz, Craig E. Pilgrim, Piet Van Solingen, Michael Ward
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Patent number: 7498159Abstract: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.Type: GrantFiled: December 3, 2007Date of Patent: March 3, 2009Assignee: Genencor International, Inc.Inventors: Toby M. Baldwin, Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz