Patents by Inventor Kathleen E. Rodgers

Kathleen E. Rodgers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for promoting erythropoiesis
    Publication number: 20090062210
    Abstract: The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists as a therapeutic adjunct. The method is useful for the treatment of congenital or acquired aplastic or hypoplastic anemia associated with chronic renal failure, end-stage renal disease, renal transplantation, cancer, AIDS, chemotherapy, radiotherapy, bone marrow transplantation and chronic diseases.
    Type: Application
    Filed: June 6, 2007
    Publication date: March 5, 2009
    Inventors: Kathleen E. Rodgers, Gere DiZerega
  • Method for Treating a Patient Undergoing Chemotherapy
    Publication number: 20080167252
    Abstract: The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood following chemotherapy, comprising administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to a patient in need of chemotherapy.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 10, 2008
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega
  • Method of promoting erythropoiesis
    Patent number: 7288522
    Abstract: The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists as a therapeutic adjunct. The method is useful for the treatment of congenital or acquired aplastic or hypoplastic anemia associated with chronic renal failure, end-stage renal disease, renal transplantation, cancer, AIDS, chemotherapy, radiotherapy, bone marrow transplantation and chronic diseases.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: October 30, 2007
    Assignee: The University of Southern California
    Inventors: Kathleen E. Rodgers, Gere DiZerega
  • Methods for treating and preventing damage to mucosal tissue
    Patent number: 7176183
    Abstract: The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing damage to mucosal tissue by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to the subject.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: February 13, 2007
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. diZerega
  • Radiation therapy methods
    Patent number: 7173011
    Abstract: The present invention provides methods and kits for mitigating radiation induced tissue damage, improving the effectiveness of radiation therapy, to support bone marrow transplantation, and promoting megakaryocyte production and mobilization and platelet production, each method comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: February 6, 2007
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere DiZerega
  • Methods for inhibiting tumor cell proliferation
    Patent number: 7122523
    Abstract: The present invention provides methods, compounds, and pharmaceutical compositions for inhibiting tumor cell proliferation, by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to a subject.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: October 17, 2006
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. diZerega
  • Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
    Patent number: 7118748
    Abstract: The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (Al), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: October 10, 2006
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. diZerega
  • Wound healing compositions
    Patent number: 7022675
    Abstract: Methods and compositions based on chemical analogs of angiotensin II and analogs of angiotensin II fragments useful for accelerating wound healing in mammals.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: April 4, 2006
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega
  • Methods for accelerating bone and cartilage growth and repair
    Patent number: 6916783
    Abstract: The present invention provides improved methods, kits, and compositions for enhancing bone, cartilage and cartilage repair, bone and prosthesis implantation, and attachment and fixation of cartilage and cartilage to bone or other tissues, and chondrocyte proliferation composing the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: July 12, 2005
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega
  • Methods for treating and preventing damage to mucosal tissue
    Patent number: 6821953
    Abstract: The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing damage to mucosal tissue by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to the subject.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: November 23, 2004
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere diZerega
  • Methods for inhibiting tumor cell proliferation
    Publication number: 20040176302
    Abstract: The present invention provides methods, compounds, and pharmaceutical compositions for inhibiting tumor cell proliferation, by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to a subject.
    Type: Application
    Filed: April 26, 2002
    Publication date: September 9, 2004
    Inventors: Kathleen E. Rodgers, Gere S. diZerega
  • Methods for treating a patient undergoing chemotherapy
    Patent number: 6762167
    Abstract: The present invention provides improved methods, kits, and pharmaccutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood following chemotherapy, comprising administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues. AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to a patient in need of chemotherapy.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: July 13, 2004
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega
  • Methods for treating and preventing alopecia
    Patent number: 6747008
    Abstract: The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing alopecia in a subject in need thereof by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to the subject.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 8, 2004
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega
  • Methods for limiting scar and adhesion formation
    Patent number: 6730775
    Abstract: The present invention provides methods, kits, and pharmaceutical compositions for limiting scar or adhesion formation by administration of angiotensinogen, AI, AI analogues, and/or AI fragments and analogues thereof, AII analogues, AII fragments or analogues thereof, ACE inhibitors, AII AT2 type 2 receptor agonists, either alone or in combination with other compounds.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: May 4, 2004
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere diZerega
  • Method of promoting production of living tissue equivalents
    Publication number: 20040033956
    Abstract: The present invention provides methods, improved cell culture medium and kits for accelerating the generation of tissue equivalents, and for improving the quality of tissue equivalents, by growth in the presence of angiotensinogen, AI, AI analogues, AI fragments and analogues thereof, AII, AII analogues, AII fragments and analogues thereof and/or AII AT2 type 2 receptor agonists.
    Type: Application
    Filed: June 18, 2002
    Publication date: February 19, 2004
    Applicant: The University of Southern California
    Inventors: Kathleen E. Rodgers, Gere DiZerega
  • Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
    Publication number: 20040006003
    Abstract: The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.
    Type: Application
    Filed: February 7, 2003
    Publication date: January 8, 2004
    Applicant: The University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. diZerega
  • Methods for accelerating bone and cartilage growth and repair
    Publication number: 20030199434
    Abstract: The present invention provides improved methods, kits, and compositions for enhancing bone cartilage and cartilage repair, bone and prosthesis implantation, and attachment and fixation of cartilage and cartilage to bone or other tissues, and chondrocyte proliferation composing the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
    Type: Application
    Filed: January 30, 2001
    Publication date: October 23, 2003
    Applicant: The University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega
  • Radiation therapy methods
    Publication number: 20030130196
    Abstract: The present invention provides methods and kits for mitigating radiation induced tissue damage, improving the effectiveness of radiation therapy, to support bone marrow transplantation, and promoting megakaryocyte production and mobilization and platelet production, each method comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
    Type: Application
    Filed: January 13, 2003
    Publication date: July 10, 2003
    Applicant: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere DiZerega
  • Methods for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood in a patient in need of chemotherapy
    Patent number: 6566335
    Abstract: The present invention provides improved methods, kits, and pharmaceutical compositions for increasing white blood cell survival following chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: May 20, 2003
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere DiZerega
  • Wound healing compositions
    Publication number: 20030017970
    Abstract: Methods and compositions based on chemical analogs of angiotensin II and analogs of angiotensin II fragments useful for accelerating wound healing in mammals.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 23, 2003
    Applicant: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. DiZerega