Patents by Inventor Kathleen J. Illig

Kathleen J. Illig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for formulation of carbapenem antibiotic compositions
    Patent number: 6548492
    Abstract: A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II: The process entails compounding a unstable, monosodium salt carbapenem with a sodium bicarbonate solution at a temperature range of from about 0° to about 5° C. while maintaining a pH between about 7.0 and about 8.0, filtering the resultant solution, bottling under sterile conditions, and lyophilizing to produce the formulation.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: April 15, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Anthony Al-Dehneh, William A. Hunke, Kathleen J. Illig, Anand Kanike, Hiren Patel, Scott D. Reynolds, Stelios C. Tsinontides
  • Formulations for therapeutic agents absorbed through mucous membranes
    Publication number: 20030054045
    Abstract: Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
    Type: Application
    Filed: June 21, 2002
    Publication date: March 20, 2003
    Applicant: Elan Pharma International Limited
    Inventors: Gary G. Liversidge, W. Mark Eickhoff, Kathleen J. Illig, Pramod Sarpotdar, Stephen B. Ruddy
  • Process for formulation of antibiotic compounds
    Patent number: 6486150
    Abstract: The present invention involves a process for preparing a stable final formulation product of a compound of formula I, or its pharmaceutically acceptable salt, hydrate or solvate by incorporating a suitable carbon dioxide source to an unstable monosodium adduct of carbapenem antibiotic compound.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: November 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: William A. Hunke, Kathleen J. Illig, Anand Kanike, Scott D. Reynolds, Stelios C. Tsinontides, Anthony S. Al-Dehneh, Hiren S. Patel
  • Methods for targeting drug delivery to the upper and/or lower gastrointestinal tract
    Patent number: 6432381
    Abstract: Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: August 13, 2002
    Assignee: Elan Pharma International Limited
    Inventors: Gary G. Liversidge, W. Mark Eickhoff, Kathleen J. Illig, Pramod Sarpotdar, Stephen B. Ruddy
  • Process for formulation of antibiotic compounds
    Publication number: 20020002160
    Abstract: The present invention involves a process for preparing a stable final formulation product of a compound of formula I, 1
    Type: Application
    Filed: April 27, 2001
    Publication date: January 3, 2002
    Inventors: William A. Hunke, Kathleen J. Illig, Anand Kanike, Scott D. Reynolds, Stelios C. Tsinontides, Anthony S. Al-Dehneh, Hiren S. Patel
  • FORMULATIONS FOR THERAPEUTIC AGENTS ABSORBED THROUGH MUCOUS MEMBRANES
    Publication number: 20010006617
    Abstract: Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
    Type: Application
    Filed: March 11, 1997
    Publication date: July 5, 2001
    Inventors: GARY G. LIVERSIDGE, W. MARK EICKHOFF, KATHLEEN J. ILLIG, PRAMOD SARPOTDAR, STEPHEN B. RUDDY
  • Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents
    Patent number: 5628981
    Abstract: Nanoparticulate crystalline x-ray contrast agents are formulated with stabilizers to enhance contact between the crystalline x-ray contrast agents and the gastrointestinal tract.Nanoparticulate crystalline therapeutic substances also formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: May 13, 1997
    Assignee: Nano Systems L.L.C.
    Inventors: Gary Liversidge, W. Mark Eickhoff, Kathleen J. Illig, Pramod Sarpotdar, Stephen B. Ruddy
  • Process of preparing x-ray contrast compositions containing nanoparticles
    Patent number: 5543133
    Abstract: A process of preparing nanoparticulate contrast agents comprising the steps of:preparing a premix of the contrast agent and a surface modifier; andsubjecting the premix to mechanical means to reduce the particle size of the contrast agent, the mechanical means producing shear, impact, cavitation and attrition.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: August 6, 1996
    Assignee: NanoSystems L.L.C.
    Inventors: Jon R. Swanson, H. William Bosch, Kathleen J. Illig, Donna M. Marcera, Ronald L. Mueller
  • Method of grinding pharmaceutical substances
    Patent number: 5518187
    Abstract: A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
    Type: Grant
    Filed: January 12, 1994
    Date of Patent: May 21, 1996
    Assignee: Nano Systems L.L.C.
    Inventors: Joseph A. Bruno, Brian D. Doty, Evan Gustow, Kathleen J. Illig, Nats Rajagopalan, Pramod Sarpotdar
  • Formulations comprising olin 10-G to prevent particle aggregation and increase stability
    Patent number: 5340564
    Abstract: This invention discloses a composition comprised of nanoparticles having p-isononylphenoxypoly (glycidol) as a surface modifier adsorbed on the surface thereof. In preferred embodiments, the p-isononylphenoxypoly (glycidol) provides resistance to particle aggregation during heat sterilization. In another preferred embodiment, those nanoparticles also comprise a stability enhancing compound. A preferred stability enhancing compound is albumin. This invention further discloses a method of making nanoparticles having p-isononylphenoxypoly(glycidol) as a surface modifier adsorbed on the surface, comprised of contacting said nanoparticles with p-isononylphenoxypoly(glycidol) for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle.
    Type: Grant
    Filed: December 10, 1992
    Date of Patent: August 23, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Kathleen J. Illig, Pramod Sarpotdar