Patents by Inventor Kathleen King

Kathleen King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HER2-transgenic non-human tumor model
    Publication number: 20020035736
    Abstract: The invention concerns HER2-transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with teh overexpression of HER2. In particular, the invention concerns animal models designed to test drug candidates for the treatment of HER2-overexpressing cancers, including breast cancer, that are not responding or poorly responding to current treatments.
    Type: Application
    Filed: March 16, 2001
    Publication date: March 21, 2002
    Inventors: Sharon Erickson, Kathleen King, Ralph Schwall
  • Use of leukemia inhibitory factor and endothelin antagonists
    Patent number: 6156733
    Abstract: A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: December 5, 2000
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Kathleen King, Elizabeth Luis, Jennie P. Mather, Nicholas F. Paoni
  • Assay for cardiac hypertrophy
    Patent number: 6117650
    Abstract: An assay to test for hypertrophic activity in myocytes is described where wells are precoated with D-MEM/F-12 and fetal calf serum, plated with myocytes, cultured, and any change in size of the cells is determined. The growth medium may contain insulin, transferrin and aprotinin.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: September 12, 2000
    Assignee: Genentech, Inc.
    Inventor: Kathleen King
  • Method of treating heart failure using leukemia inhibitory factor antagonists optionally with endothelin antagonists
    Patent number: 5837241
    Abstract: A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: November 17, 1998
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Kathleen King, Elizabeth Luis, Jennie P. Mather, Nicholas F. Paoni
  • Method of purifying cardiac hypertrophy factor
    Patent number: 5723585
    Abstract: Isolated CHF, isolated DNA encoding CHF, recombinant or synthetic methods of preparing CHF, and a method of purifying CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: March 3, 1998
    Assignee: Genentech, Inc.
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Gene encoding cardiac hypertrophy factor
    Patent number: 5679545
    Abstract: Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. These CT-1 molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: October 21, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Hybridomas producing antibodies to cardiac hypertrophy factor
    Patent number: 5627073
    Abstract: Isolated CHF (also referred to cardiac hypertrophy factor or cardiotrophin-1), isolated DNA encoding CHF, hybridomas and cell lines producing antibodies to CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: May 6, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Antibodies to cardiac hypertrophy factor and uses thereof
    Patent number: 5624806
    Abstract: Isolated CHF, isolated DNA encoding cardiac hypertrophy factor (CHF), and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 29, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy
    Patent number: 5573762
    Abstract: A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: November 12, 1996
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Kathleen King, Elizabeth Luis, Jennie P. Mather, Nicholas F. Paoni
  • Cardiac hypertrophy factor
    Patent number: 5571893
    Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed, These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: November 5, 1996
    Assignees: Genentech, Inc., Regents of the Univ. of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Detection and amplification of candiotrophin-1(cardiac hypertrophy factor)
    Patent number: 5571675
    Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: November 5, 1996
    Assignees: Genentech, Inc., Regents of the Univ. of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Cardiac hypertrophy factor and uses therefor
    Patent number: 5534615
    Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: July 9, 1996
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennice, William Wood