Patents by Inventor Kathleen M. Miller
Kathleen M. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9034346Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.Type: GrantFiled: January 24, 2012Date of Patent: May 19, 2015Assignee: Boston Scientific Scimed, Inc.Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Patent number: 8691264Abstract: Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device.Type: GrantFiled: February 24, 2012Date of Patent: April 8, 2014Assignee: Boston Scientific Scimed, Inc.Inventors: Jianmin Li, Danielle Conley, Weenna Bucay-Couto, Cang Duy Dao, Hamid Davoudi, Raymond J. Lareau, Kathleen M Miller
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Patent number: 8481138Abstract: Implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the implantable or insertable medical devices include at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.Type: GrantFiled: January 24, 2012Date of Patent: July 9, 2013Assignee: Boston Scientific Scimed, Inc.Inventors: Kathleen M Miller, Gregory T Sydney, Kurt Geitz, Peter L Dayton, Ronald A Sahatjian
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Publication number: 20120150096Abstract: Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device.Type: ApplicationFiled: February 24, 2012Publication date: June 14, 2012Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Jianmin LI, Danielle Conley, Weenna Bucay-Couto, Cang Duy Dao, Hamid Davoudi, Raymond J. Lareau, Kathleen M Miller
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Publication number: 20120128793Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device.Type: ApplicationFiled: January 24, 2012Publication date: May 24, 2012Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Publication number: 20120121665Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device.Type: ApplicationFiled: January 24, 2012Publication date: May 17, 2012Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Patent number: 8133501Abstract: Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device.Type: GrantFiled: February 28, 2003Date of Patent: March 13, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Jianmin Li, Danielle Conley, Weenna Bucay Couto, Cang Duy Dao, Hamid Davoudi, Raymond Lareau, Kathleen M. Miller
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Patent number: 8105520Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.Type: GrantFiled: January 21, 2005Date of Patent: January 31, 2012Assignee: Boston Scientific Scimed, Inc,Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Patent number: 7993390Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.Type: GrantFiled: February 27, 2004Date of Patent: August 9, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Kathleen M. Miller, Weenna Bucay-Couto, Jianmin Li
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Publication number: 20090220677Abstract: A method of manufacturing a covered stent having a sufficiently thick covering to retain a therapeutically effective amount of a therapeutic agent. The covering is applied to the entire outer surface of the stent to provide sufficient volume for retention of the therapeutic agent. In certain embodiments, the stent has a plurality of openings that are covered by the covering. The invention is particularly suited for certain applications, such as for the manufacture of non-vascular stents.Type: ApplicationFiled: May 14, 2009Publication date: September 3, 2009Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Claude O. Clerc, Kathleen M. Miller
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Publication number: 20080208325Abstract: According to an aspect of the present invention, long term medical articles are provided which include the following: (a) first and second body contacting (e.g., tissue and/or body-fluid contacting) porous polymeric layers; (b) a polymeric barrier layer disposed between the first and second porous polymer layers; and (c) a reinforcement element. According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: (a) a reinforcement element; (b) a blood contacting porous polymeric layer having a surface energy ranging between 20 and 30 dynes/cm disposed over an inner surface of the reinforcement element; and (c) an additional porous polymeric layer formed over an outer surface of the reinforcement element.Type: ApplicationFiled: February 25, 2008Publication date: August 28, 2008Applicant: Boston Scientific Scimed, Inc.Inventors: Michael N. Helmus, Barron Tenney, Yixin Xu, Kevin M. Alves, Frederick H. Strickler, Kathleen M. Miller, Mark Boden
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Patent number: 7252838Abstract: A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.Type: GrantFiled: September 17, 2002Date of Patent: August 7, 2007Assignee: Boston Scientific Scimed, Inc.Inventors: Marcia L. O'Conner, Michael S. Banik, Kathleen M. Miller
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Patent number: 6887270Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.Type: GrantFiled: February 8, 2002Date of Patent: May 3, 2005Assignee: Boston Scientific SciMed, Inc.Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Publication number: 20040249441Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device.Type: ApplicationFiled: February 27, 2004Publication date: December 9, 2004Inventors: Kathleen M. Miller, Weenna Bucay-Couto, Jianmin Li
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Publication number: 20040157082Abstract: An embolic material comprising a polymerizable hydrophobic suspension of coated magnetically responsive particles (e.g. magnetite Fe3O4) suspended in a solvent monomer, a bulking agent, a radiopaque monomer, and an accelerant, and an initiator. The coated magnetically responsive particles preferably have a diameter of between about 20 and about 40 nm, and a magnetically responsive core with a diameter of between about 2 and about 20 nm.Type: ApplicationFiled: July 21, 2003Publication date: August 12, 2004Inventors: Rogers C. Ritter, Jonathan Harburn, Christopher Spilling, Kathleen M. Miller
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Publication number: 20030224033Abstract: Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device.Type: ApplicationFiled: February 28, 2003Publication date: December 4, 2003Inventors: Jianmin Li, Danielle Conley, Weenna Bucay Couto, Cang Duy Dao, Hamid Davoudi, Raymond Lareau, Kathleen M. Miller
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Publication number: 20030153983Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device.Type: ApplicationFiled: February 8, 2002Publication date: August 14, 2003Applicant: Scimed Life Systems, Inc.Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Publication number: 20030012806Abstract: A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.Type: ApplicationFiled: September 17, 2002Publication date: January 16, 2003Inventors: Marcia McBride-Sakal, Michael S. Banik, Kathleen M. Miller
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Patent number: 6471987Abstract: A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.Type: GrantFiled: June 9, 1999Date of Patent: October 29, 2002Assignee: Scimed Life Systems, Inc.Inventors: Marcia McBride-Sakal, Michael S. Banik, Kathleen M. Miller
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Patent number: 6174513Abstract: Surfactants alone or in combination with salts are used to stabilize radiolabeled peptides and proteins contained in diagnostic or therapeutic radiopharmaceutical compositions.Type: GrantFiled: July 30, 1998Date of Patent: January 16, 2001Assignee: MallincKrodt Inc.Inventors: Kathleen M. Miller, Laurence de La Fourniere