Patents by Inventor Kathleen McFadden

Kathleen McFadden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease inhibitor peptides
    Patent number: 6906033
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: June 14, 2005
    Assignee: SCIOS NOVA, Inc.
    Inventors: R. Tyler White, Deborah Damm, David D. Lesikar, Kathleen McFadden, Brett L. Garrick
  • Protease inhibitor peptides
    Patent number: 6613890
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: September 2, 2003
    Assignee: Scios, Inc.
    Inventors: R. Tyler White, Deborah Damm, David D. Lesikar, Kathleen McFadden, Brett L. Garrick
  • Protease inhibitor peptides
    Publication number: 20030114372
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Application
    Filed: February 19, 2002
    Publication date: June 19, 2003
    Inventors: R. Tyler White, Deborah Damm, David D. Lesikar, Kathleen McFadden, Brett L. Garrick
  • PROTEASE INHIBITOR PEPTIDES
    Publication number: 20030017546
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Application
    Filed: January 21, 1999
    Publication date: January 23, 2003
    Inventors: R. TYLER WHITE, DEBORAH DAMM, DAVID D. LESIKAR, KATHLEEN MCFADDEN, BRETT L. GARRICK
  • Protease inhibitor peptides
    Patent number: 6376648
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: April 23, 2002
    Assignee: Scios Nova, Inc.
    Inventors: R. Tyler White, Deborah Damm, David D. Lesikar, Kathleen McFadden, Brett L. Garrick
  • PROTEASE INHIBITOR PEPTIDES
    Publication number: 20010020003
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Application
    Filed: January 21, 1999
    Publication date: September 6, 2001
    Inventors: R. TYLER WHITE, DEBORAH DAMM, DAVID D. LESIKAR, KATHLEEN MCFADDEN, BRETT L. GARRICK
  • Protease inhibitor peptides
    Patent number: 5962266
    Abstract: Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: October 5, 1999
    Assignee: Scios, Inc.
    Inventors: R. Tyler White, Deborah Damm, David D. Lesikar, Kathleen McFadden, Brett L. Garrick