Abstract: A contact lens package includes a sealed contact lens package and a wrap coupled to the sealed contact lens package. The wrap has one or more panels. One of more of the panels includes a printed surface that includes a unique device identifier, which is provided in both human readable form that includes numbers or letters, or both, and machine readable form, such as a bar code. A method of manufacturing a contact lens package includes providing the sealed contact lens package and coupling the wrap to the sealed contact lens package.

Abstract: A contact lens package includes a sealed contact lens package and a wrap coupled to the sealed contact lens package. The wrap has one or more panels. One of more of the panels includes a printed surface that includes a unique device identifier, which is provided in both human readable form that includes numbers or letters, or both, and machine readable form, such as a bar code. A method of manufacturing a contact lens package includes providing the sealed contact lens package and coupling the wrap to the sealed contact lens package.

Abstract: Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.

Abstract: 2 The invention generally relates to food quality indicators and, more particularly, to improved adhesive food quality indicators and their use and manufacture. The food quality indicators (FQI) of the invention are advantageously simple and low cost but sensitive devices for detecting unhealthy levels of food spoilage products in a sealed food product package. The FQI is affixed to a breathable or gas-permeable wrap around the product, and a visual indicator region in the FQI that is sensitive to the presence of food breakdown products allows the end user, by visual observation to determine whether microbial spoilage has occurred.

Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

Abstract: A method and device for sensing food quality includes a detection material having an inherent sensitivity to a contaminant and changing a property in response thereto. The detection material is subjected to a modulating agent to alter the sensitivity of the detection material, so that exposure of the detection material to the contaminant causes the property to change in response to a level corresponding to the altered detection sensitivity.

Abstract: Indicators for detecting food spoilage and related methods utilize a matrix having at least one surface for establishing fluid communication with a food to be monitored, and, physically associated with (e.g., entrained within or bonded to) the matrix, an amine-responsive compound that itself comprises or consists of a betalain (or derivative thereof), a flavonoid (or derivative thereof), or a combination of these.

Abstract: Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.

Abstract: Methods are provided for delivering oligonucleotide compounds into osteoclasts or osteoclast precursor cells. The compounds according to one embodiment are targeted to a nucleic acid encoding RANK and are capable of modulating the expression of RANK. Also provided are methods for modulating osteoclast differentiation by delivering such compounds into osteoclast precursor cells. Cellular delivery of the oligonucleotide compounds may be carried out by transfecting the compounds into osteoclasts or osteoclast precursor cells in the presence of a non-liposomal transfection agent. Examples of suitable non-liposomal transfection agents include FuGENE 6 and Effectene®. The disclosed methods may be advantageously applied in the discovery of diagnostics and therapeutics for bone diseases associated with osteoclast activity.

Abstract: Compounds, compositions and methods are provided for modulating the expression of Angiopoietin-2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Angiopoietin-2. Methods of using these compounds for modulation of Angiopoietin-2 expression and for diagnosis and treatment of disease associated with expression of Angiopoietin-2 are provided.