Patents by Inventor Kathleen R. Manna
Kathleen R. Manna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8546482Abstract: This invention provides stable aqueous compositions including stable coating compositions, and methods of their production. The stable aqueous compositions and stable aqueous coating compositions comprise one or more emulsion-polymerized addition polymer, one or more carboxylesterase enzyme, and one or more carboxylesterase deactivating agent, such that the ester hydrolysis activity in the composition is less than 0.010 micromole/minute, and wherein the aqueous composition has a headspace volatile organic compound (VOC) content, as measured by headspace gas chromatography-mass spectrometry (GC-MS) at 33° C., of less than 10 ppm of organic carboxylester with a normal boiling point of less than 150° C. and more than 50 ppm of mono-alcohol with a formula molecular weight of less than 76.Type: GrantFiled: December 10, 2010Date of Patent: October 1, 2013Assignee: Rohm and Haas CompanyInventors: James Bohling, Paul F. Doll, David L. Frattarelli, Kathleen R. Manna, Alvin M. Maurice
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Patent number: 8524809Abstract: This invention provides stable aqueous compositions including stable coating compositions, and methods of their production. The stable aqueous compositions and stable aqueous coating compositions comprise i) an aqueous dispersion of one or more emulsion-polymerized addition polymer comprising polymerized units of one or more carboxylester monomer, wherein at least one carboxylester monomer is a vinyl ester monomer; ii) one or more carboxylesterase enzyme; iii) one or more mono-alcohol with a formula molecular weight of less than 76; iv) optionally, acetaldehyde; and v) optionally, one or more organic carboxylester with a normal boiling point of less than 150° C.; and wherein the aqueous composition has a headspace volatile organic compound (VOC) content, as measured by headspace gas chromatography-mass spectrometry (GC-MS) at 33° C.Type: GrantFiled: December 10, 2010Date of Patent: September 3, 2013Assignee: Rohm and Haas CompanyInventors: James Bohling, Paul F. Doll, David L. Frattarelli, Kathleen R. Manna, Alvin M. Maurice
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Publication number: 20110166257Abstract: This invention provides stable aqueous compositions including stable coating compositions, and methods of their production. The stable aqueous compositions and stable aqueous coating compositions comprise i) an aqueous dispersion of one or more emulsion-polymerized addition polymer comprising polymerized units of one or more carboxylester monomer, wherein at least one carboxylester monomer is a vinyl ester monomer; ii) one or more carboxylesterase enzyme; iii) one or more mono-alcohol with a formula molecular weight of less than 76; iv) optionally, acetaldehyde; and v) optionally, one or more organic carboxylester with a normal boiling point of less than 150° C.; and wherein the aqueous composition has a headspace volatile organic compound (VOC) content, as measured by headspace gas chromatography-mass spectrometry (GC-MS) at 33° C.Type: ApplicationFiled: December 10, 2010Publication date: July 7, 2011Inventors: James Bohling, Paul F. Doll, David E. Frattarelli, Kathleen R. Manna, Alvin M. Maurice
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Publication number: 20110152406Abstract: This invention provides stable aqueous compositions including stable coating compositions, and methods of their production. The stable aqueous compositions and stable aqueous coating compositions comprise one or more emulsion-polymerized addition polymer, one or more carboxylesterase enzyme, and one or more carboxylesterase deactivating agent, such that the ester hydrolysis activity in the composition is less than 0.010 micromole/minute, and wherein the aqueous composition has a headspace volatile organic compound (VOC) content, as measured by headspace gas chromatography-mass spectrometry (GC-MS) at 33° C., of less than 10 ppm of organic carboxylester with a normal boiling point of less than 150° C. and more than 50 ppm of mono-alcohol with a formula molecular weight of less than 76.Type: ApplicationFiled: December 10, 2010Publication date: June 23, 2011Inventors: James Bohling, Paul F. Doll, David L. Frattarelli, Kathleen R. Manna, Alvin M. Maurice
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Patent number: 6890752Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.Type: GrantFiled: June 28, 2001Date of Patent: May 10, 2005Assignees: The University of Kentucky Research Foundation, The Salk Institute for Biological StudiesInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Publication number: 20040053386Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.Type: ApplicationFiled: June 28, 2001Publication date: March 18, 2004Applicants: The University of Kentucky Research Foundation and The Salk Institute for Biological Studies, Kentucky and California corporationsInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Patent number: 6645762Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.Type: GrantFiled: July 6, 2001Date of Patent: November 11, 2003Assignees: The Salk Institute for Biological Studies, The University of Kentucky Research FoundationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Patent number: 6569656Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.Type: GrantFiled: July 11, 2001Date of Patent: May 27, 2003Assignees: The University of Kentucky Research Foundation, The Salk Institute for Biological StudiesInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Publication number: 20030087406Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.Type: ApplicationFiled: July 6, 2001Publication date: May 8, 2003Applicant: The University of Kentucky Research FoundationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Patent number: 6559297Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.Type: GrantFiled: June 29, 2001Date of Patent: May 6, 2003Assignees: The Salk Institute for Biological Studies, The University of Kentucky Research FoundationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Patent number: 6495354Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.Type: GrantFiled: June 22, 2001Date of Patent: December 17, 2002Assignees: University of Kentucky Research Foundation, The Salk Institute for Biological StudiesInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Patent number: 6468772Abstract: Novel polypeptides and the corresponding nucleic acids encoding such polypeptides are disclosed herein. The invention provides methods of making modified polypeptides by altering one or more amino acid residues involved in the active site of a preselected polypeptide.Type: GrantFiled: September 17, 1999Date of Patent: October 22, 2002Assignees: The Salk Institute for Biological Studies, The University of Kentucky Research FoundationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Publication number: 20020094556Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.Type: ApplicationFiled: June 22, 2001Publication date: July 18, 2002Applicant: The University of Kentucky Research FoundationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Publication number: 20020094557Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.Type: ApplicationFiled: July 11, 2001Publication date: July 18, 2002Applicant: The University of Kentucky Research FoundationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
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Publication number: 20020040488Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.Type: ApplicationFiled: June 29, 2001Publication date: April 4, 2002Applicant: The University of Kentucky Research Foundation, Kentucky corporationInventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks