Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: Using a combination of inertial sensors (accelerometers 70, 80, 90, 170, 180, 190) and, perhaps, a digital compass, a device can record movement in all directions relative to an origin (300), or initial position. Once the device has captured the information, it can calculate heading and distance from the current position back to the origin (160). Other navigational equipment relies on signals from global positioning system (GPS) satellites and, thus, will not function properly in urban canyons or inside buildings of any sort. This device can determine direction and distance under nearly any circumstances and has a small footprint that will allow the embedding of it into nearly any consumer electronic device (10). The consumer electronic device can then display a directional arrow (30), or the distance to the origin (40) alongside other relevant information. One obvious use of the invention is to find your parked vehicle (60) (also known as a “vehicle locator”).

Abstract: Using a combination of inertial sensors (accelerometers 70, 80, 90, 170, 180, 190) and, perhaps, a digital compass, a device can record movement in all directions relative to an origin (300), or initial position. Once the device has captured the information, it can calculate heading and distance from the current position back to the origin (160). Other navigational equipment relies on signals from global positioning system (GPS) satellites and, thus, will not function properly in urban canyons or inside buildings of any sort. This device can determine direction and distance under nearly any circumstances and has a small footprint that will allow the embedding of it into nearly any consumer electronic device (10). The consumer electronic device can then display a directional arrow (30), or the distance to the origin (40) alongside other relevant information. One obvious use of the invention is to find your parked vehicle (60) (also known as a “vehicle locator”).