Patents by Inventor Kathleen Triplett

Kathleen Triplett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VLP-based vaccines for targeting secreted virulence factors
    Patent number: 10821167
    Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: November 3, 2020
    Assignee: UNM Rainforest Innovations
    Inventors: Pamela Hall, Bryce Chackerian, David S. Peabody, Seth Michael Daly, Bradley Owen Elmore, Kathleen Triplett
  • VLP-BASED VACCINES FOR TARGETING STAPHYLOCOCCUS AUREUS SECRETED VIRULENCE FACTORS
    Publication number: 20190038735
    Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.
    Type: Application
    Filed: February 1, 2017
    Publication date: February 7, 2019
    Inventors: Pamela Hall, Bryce Chackerian, David S. Peabody, Seth Michael Daly, Bradley Owen Elmore, Kathleen Triplett