Patents by Inventor Kathryn E. Uhrich

Kathryn E. Uhrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oral care compositions and uses thereof
    Patent number: 10744079
    Abstract: Described herein are oral care compositions comprising amphiphilic macromolecules, along with methods of making and using same.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: August 18, 2020
    Assignees: Colgate-Palmolive Company, Rutgers, the State University of New Jersey
    Inventors: Carl Myers, Guillaume Picquet, Kathryn E. Uhrich, Jennifer Chan Woo, Jeannette Elizabeth Marine
  • Antibacterial agents
    Patent number: 10556856
    Abstract: The invention provides an antibacterial compound of formula I: or a salt thereof, as well as an antibacterial compound of formula II: or a salt thereof, wherein R1, R2, X, Y and n have any of the values defined in the specification.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: February 11, 2020
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Allison Faig
  • Antibacterial Agents
    Publication number: 20190119199
    Abstract: The invention provides an antibacterial compound of formula I: or a salt thereof, as well as an antibacterial compound of formula II: or a salt thereof, wherein R1, R2, X, Y and n have any of the values defined in the specification.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 25, 2019
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Allison Faig
  • Oral Care Compositions and Uses Thereof
    Publication number: 20190060210
    Abstract: Described herein are oral care compositions comprising amphiphilic macromolecules, along with methods of making and using same.
    Type: Application
    Filed: August 22, 2018
    Publication date: February 28, 2019
    Applicants: Colgate-Palmolive Company, Rutgers, the State University of New Jersey
    Inventors: Carl MYERS, Guillaume PICQUET, Kathryn E. UHRICH, Jennifer CHAN WOO, Jeannette Elizabeth MARINE
  • Antibacterial agents
    Patent number: 10138203
    Abstract: The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, X, Y and n have any of the values defined in the specification.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: November 27, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Allison Faig
  • Process and intermediates for preparing poly(anhydride-esters)
    Patent number: 10023521
    Abstract: Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is independently a leaving group; and wherein X is a residue of a biologically active compound.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: July 17, 2018
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Kathryn E. Uhrich, Jonathan J. Faig, Kervin Smith
  • Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity
    Patent number: 10016517
    Abstract: The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 10, 2018
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Adam W. York, Prabhas V. Moghe, Kathryn E. Uhrich, Robert Prud'homme
  • Polymers and methods thereof for wound healing
    Patent number: 9782432
    Abstract: Certain embodiments of the invention provide a copolymer having a backbone, wherein the backbone comprises a) one or more units that comprise a group that will yield a biologically active agent upon hydrolysis of the backbone; and b) one or more units of formula (II): wherein y is 1 or more. Other embodiments of the invention provide a therapeutic method for treating a wound in an animal comprising administering to an animal in need of such therapy, an effective amount of a copolymer as described herein.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: October 10, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Sabrina S. Snyder
  • ANTIBACTERIAL AGENTS
    Publication number: 20170217878
    Abstract: The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, X, Y and n have any of the values defined in the specification.
    Type: Application
    Filed: June 15, 2015
    Publication date: August 3, 2017
    Applicant: Rutgers, the State University of New Jersey
    Inventors: Kathryn E. Uhrich, Allison Faig
  • PROCESS AND INTERMEDIATES FOR PREPARING POLY(ANHYDRIDE-ESTERS)
    Publication number: 20170121267
    Abstract: Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is independently a leaving group; and wherein X is a residue of a biologically active compound.
    Type: Application
    Filed: June 10, 2015
    Publication date: May 4, 2017
    Applicant: Rutgers, the State University of New Jersey
    Inventors: Kathryn E. Uhrich, Jonathan J. Faig, Kervin Smith
  • Amphiphilic macromolecules and methods of use thereof
    Patent number: 9630905
    Abstract: Certain embodiments of the invention provide a compound of formula (I): A-X—Y—Z—R1??(I), or a salt thereof, wherein A, X, Y, Z and R1 have any of the values defined in the specification, and methods of use thereof. For example, certain embodiments of the invention provide a method for inhibiting atherosclerosis or atherosclerotic development in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 25, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Prabhas Moghe, Dalia Abdelhamid, Li Gu, Yingyue Zhang
  • Macromolecules for treating atherosclerosis
    Patent number: 9434681
    Abstract: The invention includes compounds of the formula I and formula II and salts thereof, as well as methods for using the compounds of formula I and formula II for treating atherosclerosis. The invention also includes compounds of formula III and (2l) and salts thereof, as well as methods of using the compounds of formula III and (2l) for treating atherosclerosis. The invention also includes methods of encapsulating molecules using the compounds of the invention.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: September 6, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Dawanne E. Poree, Prabhas Moghe
  • Therapeutic compositions for bone repair
    Patent number: 9387250
    Abstract: Individuals having diabetes are more prone to fractures, periodontitis, and other bone related issues as compared to healthy individuals. Furthermore, bone healing in diabetic patients is prolonged. The invention provides a method for decreasing bone resorption or increasing bone formation or promoting bone healing in diabetic patients. In particular, a biodegradeable polymer, such as a polyanhydride salicylate is administered at or near a bone defect site, and upon hydrolysis of the polymer will releases biologically active salicylic acid.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: July 12, 2016
    Assignees: Rutgers, The State University of New Jersey, The Trustees of the University of Pennsylvania
    Inventors: Kathryn E. Uhrich, Dana Graves, Keisuke Wada, Joseph P. Fiorellini, Michelle Morano, Roselin Rosario-Meléndez, Sabrina Sachiko Snyder
  • POLYMERS AND METHODS THEREOF FOR WOUND HEALING
    Publication number: 20160175343
    Abstract: Certain embodiments of the invention provide a copolymer having a backbone, wherein the backbone comprises a) one or more units that comprise a group that will yield a biologically active agent upon hydrolysis of the backbone; and b) one or more units of formula (II): wherein y is 1 or more. Other embodiments of the invention provide a therapeutic method for treating a wound in an animal comprising administering to an animal in need of such therapy, an effective amount of a copolymer as described herein.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Kathryn E. Uhrich, Sabrina S. Snyder
  • AMPHIPHILIC MACROMOLECULES AND METHODS OF USE THEREOF
    Publication number: 20160068467
    Abstract: Certain embodiments of the invention provide a compound of formula (I): A-X—Y—Z—R1??(I), or a salt thereof, wherein A, X, Y, Z and R1 have any of the values defined in the specification, and methods of use thereof. For example, certain embodiments of the invention provide a method for inhibiting atherosclerosis or atherosclerotic development in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 8, 2015
    Publication date: March 10, 2016
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Kathryn E. Uhrich, Prabhas Moghe, Dalia Abdelhamid, Li Gu, Yingyue Zhang
  • Polyesters and methods of use thereof
    Patent number: 9144579
    Abstract: The invention provides polymers and methods for the treatment of pain and inflammation.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: September 29, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Roselin Rosario-Melendez
  • MACROMOLECULES FOR TREATING ATHEROSCLEROSIS
    Publication number: 20150175528
    Abstract: The invention includes compounds of the formula I and formula II and salts thereof, as well as methods for using the compounds of formula I and formula II for treating atherosclerosis. The invention also includes compounds of formula III and (2l) and salts thereof, as well as methods of using the compounds of formula III and (2l) for treating atherosclerosis. The invention also includes methods of encapsulating molecules using the compounds of the invention.
    Type: Application
    Filed: June 17, 2013
    Publication date: June 25, 2015
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Kathryn E. Uhrich, Dawanne E. Poree, Prabhas Moghe
  • BIOACTIVE AMPHIPHILIC POLYMER STABILIZED NANOPARTICLES WITH ENHANCED STABILITY AND ACTIVITY
    Publication number: 20140328763
    Abstract: The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 6, 2014
    Applicants: THE TRUSTEES OF PRINCETON UNIVERSITY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Adam W. York, Prabhas V. Moghe, Kathryn E. Uhrich, Robert Prud'homme
  • Amphiphilic macromolecules for nucleic acid delivery
    Patent number: 8846850
    Abstract: The invention provides amphiphilic macromolecules that are useful for delivering nucleic acids to cells and that are useful as delivery agents for gene therapy.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 30, 2014
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Kathryn E. Uhrich, Sarah M. Sparks, Li Gu, Alex Harmon, Charles M. Roth, Carolyn Federici
  • THERAPEUTIC COMPOSITIONS FOR BONE REPAIR
    Publication number: 20140271864
    Abstract: Individuals having diabetes are more prone to fractures, periodontitis, and other bone related issues as compared to healthy individuals. Furthermore, bone healing in diabetic patients is prolonged. The invention provides a method for decreasing bone resorption or increasing bone formation or promoting bone healing in diabetic patients. In particular, a biodegradeable polymer, such as a polyanhydride salicylate is administered at or near a bone defect site, and upon hydrolysis of the polymer will releases biologically active salicylic acid.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 18, 2014
    Applicants: The Trustees of the University of Pennsylvania, Rutgers, the State University of New Jersey
    Inventors: Kathryn E. Uhrich, Dana Graves