Patents by Inventor Kathryn F. Sykes

Kathryn F. Sykes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of
    Patent number: 8435533
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: May 7, 2013
    Assignees: Auburn University, Board of Regents, The University of Texas System
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • METHODS AND MATERIALS FOR PRODUCING POLYPEPTIDES IN VITRO
    Publication number: 20120316078
    Abstract: Methods for producing polypeptides in vitro are described that use free template nucleic acids that are not immobilized on a substrate. Polypeptides that are produced can be captured on particles without the use of capture agents and can be used to produce polypeptide arrays.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 13, 2012
    Inventors: Kathryn F. Sykes, Zhan-Gong Zhao, Stephen Albert Johnston, Andrey Loskutov
  • Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of
    Patent number: 8298542
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: October 30, 2012
    Assignees: Auburn University, Board of Regents, The University of Texas System
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • Method and compositions for vaccination comprising nucleic acid and/or polypeptide sequence of chlamydia
    Patent number: 8206724
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: June 26, 2012
    Assignees: Auburn University, Board of Regents, The University of Texas System
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • Methods and Compositions for Vaccination Comprising Nucleic Acid and/or Polypeptide Sequences of Chlamydia
    Publication number: 20100316662
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
    Type: Application
    Filed: August 2, 2010
    Publication date: December 16, 2010
    Applicant: AUBURN UNIVERSITY
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of
    Patent number: 7811592
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: October 12, 2010
    Assignees: Auburn University, Board of Regents, The University of Texas System
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • Method of vaccination comprising linear and circular expression elements
    Patent number: 7049098
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: May 23, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Patent number: 7018833
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: March 28, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Method of screening for a biological response using linear and circular expression elements
    Patent number: 6900018
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: May 31, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Methods for vaccine identification and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the herpesvirus family
    Publication number: 20040197347
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a herpesvirus genome, in particular an HSV-1 genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation technique.
    Type: Application
    Filed: September 23, 2003
    Publication date: October 7, 2004
    Applicants: Board of Regents, The University of Texas System, MacroGenics, Inc.
    Inventors: Kathryn F. Sykes, Katherine S. Hale, Stephen A. Johnston
  • Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of Chlamydia psittaci
    Publication number: 20030185848
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening the Chlamydia psittaci genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses in bovines or other non-human animals. The ability of an antigen to produce an immune response may be employed in vaccination of bovines or antibody preparation techniques.
    Type: Application
    Filed: December 15, 2000
    Publication date: October 2, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • Open reading frame detection compositions and methods
    Publication number: 20030166266
    Abstract: The present invention relates to a series of plasmid-based expression vectors and methods for systematically screening entire genomes for gene-coding fragments. The compositions and methods described herein facilitate the detection of open reading frames within a DNA sequence. In this manner, the ORF selection vectors of the invention may be utilized in the isolation of genetic vaccine candidates for expression library immunization.
    Type: Application
    Filed: December 1, 2000
    Publication date: September 4, 2003
    Inventors: Irene Teresa Rombel, Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20030138784
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: July 24, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of chlamydia
    Publication number: 20020183272
    Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
    Type: Application
    Filed: December 17, 2001
    Publication date: December 5, 2002
    Inventors: Stephen A. Johnston, Katherine Stemke-Hale, Kathryn F. Sykes, Bernhard Kaltenboeck
  • Linear and circular expression elements
    Publication number: 20020160402
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 31, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20020155508
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 24, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20020150940
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 17, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20020146733
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 10, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Methods of screening open reading frames to determine whether they encode polypeptides with an ability to generate an immune response
    Patent number: 6410241
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: June 25, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston