Abstract: Recent literature on SARS-CoV-2 pathogenesis has suggested that the induction of substantial acute respiratory distress phenotypes is driven by a mismatched inflammatory response together with broad vascular dysfunction. While several detailed reports implementing multi-omic approaches have provided insight into the immune cell phenotypes involved in these processes, risk stratifying markers specific to COVID-19 and the vasculature have not been explored. Provided herein is a comprehensive, multi-omics-based description of the molecular antecedents to COVID-19 mortality, yielding new insights pertaining to the vasculature while highlighting the urgent need for clinical translation of novel biomarkers for disease prognosis.

Abstract: A best practice idea is received from a requester. The best practice idea is assigned to an ownership team and a functional champion within the organization. The process ownership team and the functional champion analyze the best practice idea to confirm that the best practice idea is a best practice, assess the feasibility of the best practice, and are responsible for the development and implementation of the best practice idea. The best practice idea is presented to an executive sponsor for approval and commitment. The executive sponsor possesses the executive authority to exercise organizational resources necessary to develop and implement the best practice idea. A project plan is developed for the best practice idea to track any necessary steps for developing and implementing the best practice idea. The best practice idea is developed according to the project plan and deployed within at least one organizational function.

Abstract: An apparatus for spreading and depositing a viscous liquid or paste-like material on a substrate includes a housing removably insertable into a diamond- or square-shaped squeegee blade holder, the blade holder itself mounted to a squeegee head assembly of a screen or stencil printer. The squeegee head assembly is driven in a linear direction over and above the substrate, dragging the blade over the substrate and forcing deposition of the material onto the substrate. The housing includes a pair of oppositely-disposed locking clamps that attach to both ends of the housing. A shaft having a blade secured thereto is disposed through the channels of the clamps and within a groove of the housing, and the shaft is rotatable within the housing and the locking clamps so that the angle of attack between the blade and substrate can be selectively adjusted and, once the appropriate angle of application is selected, the blade is fixed in position by tightening the clamps against the shaft.