Abstract: Techniques for modifying the surface of implantable devices, such as bioprosthetic valves, to improve the biocompatibility of the implantable devices are provided. In particular, a customizable, non-fouling surface coating may be formed on the surface of implantable devices that improves the biocompatibility of the implantable devices and has the potential to further reduce the occurrence of complications for patients of all ages. Additionally, various molecules of interest to specifically promote endothelialization of the implantable device may be added to the surface coating, which may facilitate the formation of an endothelial layer on the surface of the implantable device that would naturally maintain a non-thrombogenic, non-immunogenic environment in the long-term.

Abstract: Techniques for modifying the surface of implantable devices, such as bioprosthetic valves, to improve the biocompatibility of the implantable devices are provided. In particular, a customizable, non-fouling surface coating may be formed on the surface of implantable devices that improves the biocompatibility of the implantable devices and has the potential to further reduce the occurrence of complications for patients of all ages. Additionally, various molecules of interest to specifically promote endothelialization of the implantable device may be added to the surface coating, which may facilitate the formation of an endothelial layer on the surface of the implantable device that would naturally maintain a non-thrombogenic, non-immunogenic environment in the long-term.

Abstract: A tissue equivalent and method of making and using same is provided herein. The tissue equivalent disclosed herein is particularly useful in the repair or replacement of mitral valve chordae, and is prepared by combining collagen with living tissue cells to form a collagen gel and controlling shrinkage of the collagen gel to cause collagen fibrils in the collagen gel to align along a single axis in an unbranched configuration or multiple paths in a branched configuration.