Patents by Inventor Kathryn L. Armour

Kathryn L. Armour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
    Patent number: 6676924
    Abstract: A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less immunogenic in a heterologous host than, the parental murine monoclonal antibody A preferred murine Class III, anti-CEA monoclonal antibody is the MN-14 antibody and the preferred heterologous antibody is from a human. Also provided are DNA constructs and vectors for producing the humanized monoclonal antibodies, and diagnostic and therapeutic conjugates using same.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: January 13, 2004
    Assignee: Immunomedics, Inc.
    Inventors: Hans J. Hansen, Kathryn L. Armour
  • CDR-GRAFTED TYPE III ANTI-CEA HUMANIZED MOUSE MONOCLONAL ANTIBODIES
    Publication number: 20020018750
    Abstract: A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less immunogenic in a heterologous host than, the parental murine monoclonal antibody A preferred murine Class III, anti-CEA monoclonal antibody is the MN-14 antibody and the preferred heterologous antibody is from a human. Also provided are DNA constructs and vectors for producing the humanized monoclonal antibodies, and diagnostic and therapeutic conjugates using same.
    Type: Application
    Filed: February 22, 1999
    Publication date: February 14, 2002
    Inventors: HANS J. HANSEN, KATHRYN L. ARMOUR
  • CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
    Patent number: 5874540
    Abstract: A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less immunogenic in a heterologous host than, the parental murine monoclonal antibody A preferred murine Class III, anti-CEA monoclonal antibody is the MN-14 antibody and the preferred heterologous antibody is from a human. Also provided are DNA constructs and vectors for producing the humanized monoclonal antibodies, and diagnostic and therapeutic conjugates using same.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: February 23, 1999
    Assignee: Immunomedics, Inc.
    Inventors: Hans J. Hansen, Kathryn L. Armour
  • Recombinant human anti-human immunodeficiency virus antibody
    Patent number: 5607847
    Abstract: The present invention provides human monoclonal antibodies, derived from the murine mAb NM-01 (PCT/US92/07111), which are specifically reactive with HIV gp120 and have the capacity to neutralize the infection of H9 cells in culture by live HIV-1 strains MN and III.sub.B as shown by reverse transcriptase, p24 and syncytium formation assays. These antibodies were shown to be as or more effective than the parent murine antibody by the aforementioned criteria.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: March 4, 1997
    Assignee: Nissin Shokuhin Kabushiki Kaisha
    Inventors: William J. Harris, Francis J. Carr, Kathryn L. Armour