Abstract: A contamination avoidance garment for emergency egress during nuclear, biological, and chemical (NBC) events is described. The garment is comprised of a single item, or of multiple garment pieces, and is configured so as to afford the wearer a high degree of barrier to a toxic environment while evacuating to a toxic free area. The garment is designed for easy donning and doffing, and combines the performance characteristics of both continuous film-based barrier composites and toxic vapor adsorbing fabrics. The garment is configured to reduce the influx of toxic chemicals by preferentially controlling pressure differentials within the garment by filtering the air entering various garment openings such as sleeve-ends, neck openings, front openings, leg-openings, and/or specifically designed environmental filtration panels.