Patents by Inventor Kathy R. Lieberman

Kathy R. Lieberman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions, devices, systems, and methods for using a nanopore
    Patent number: 9481908
    Abstract: The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: November 1, 2016
    Assignee: The Regents of the University of California
    Inventors: Felix A. Olasagasti, Kathy R. Lieberman, Seico Benner, Mark A. Akeson
  • Compositions, Devices, Systems, and Methods for Using a Nanopore
    Publication number: 20140255918
    Abstract: The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 11, 2014
    Applicant: The Regents of the University of California
    Inventors: Felix A. Olasagasti, Kathy R. Lieberman, Seico Benner, Mark A. Akeson
  • CONTROL OF DNA MOVEMENT IN A NANOPORE AT ONE NUCLEOTIDE PRECISION BY A PROCESSIVE ENZYME
    Publication number: 20140051068
    Abstract: The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. Of particular note is the stability of the system in a saline medium and to detect individual nucleotide bases in a polynucleotide in real time and which may be used to sequence DNA for many hours without change of reagents. The invention is of particular use in the fields of forensic biology, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
    Type: Application
    Filed: September 7, 2011
    Publication date: February 20, 2014
    Applicant: The Regents of the University of California
    Inventors: Gerald Maxwell Cherf, Kathy R. Lieberman, Christopher Evan Lam, Michael Doody, Mark A. Akeson