Patents by Inventor Kathy Siminovitch

Kathy Siminovitch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing and treating rheumatoid arthritis and osteoarthritis
    Patent number: 7776313
    Abstract: The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: August 17, 2010
    Assignees: University Health Network, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eleanor Fish, Carole Galligan, Kathy Siminovitch, Omar Perez, Edward Keystone, Vivian Bykerk
  • Methods of diagnosing and treating rheumatoid arthritis and osteoarthritis
    Publication number: 20070292881
    Abstract: The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.
    Type: Application
    Filed: May 25, 2007
    Publication date: December 20, 2007
    Inventors: Eleanor Fish, Carole Galligan, Kathy Siminovitch, Omar Perez, Edward Keystone, Vivian Bykerk
  • Crohn's disease-related polymorphisms
    Patent number: 6869762
    Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: March 22, 2005
    Assignees: Whitehead Institute for Biomedical Research, Ellipsis Biotherapeutics Corporation
    Inventors: Mark Daly, Thomas J. Hudson, Eric S. Lander, John Rioux, Kathy Siminovitch