Patents by Inventor Kathy Tomkinson

Kathy Tomkinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metalloprotease activation of myostatin, and methods of modulating myostatin activity
    Patent number: 7572599
    Abstract: It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: August 11, 2009
    Assignees: The Johns Hopkins University School of Medicine, Wisconsin Alumni Research Foundation, Wyeth
    Inventors: Se-Jin Lee, Alexandra C. McPherron, Daniel S. Greenspan, William N. Pappano, Neil Wolfman, Kathy Tomkinson
  • Metalloprotease activation of myostatin, and methods of modulating myostatin activity
    Publication number: 20060275280
    Abstract: It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
    Type: Application
    Filed: August 2, 2006
    Publication date: December 7, 2006
    Inventors: Se-Jin Lee, Alexandra McPherron, Daniel Greenspan, William Pappano, Neil Wolfman, Kathy Tomkinson
  • Metalloprotease activation of myostatin, and methods of modulating myostatin activity
    Publication number: 20050043232
    Abstract: It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
    Type: Application
    Filed: September 16, 2003
    Publication date: February 24, 2005
    Inventors: Se-Jin Lee, Alexandra McPherron, Daniel Greenspan, William Pappano, Neil Wolfman, Kathy Tomkinson
  • Metalloprotease activation of myostatin, and methods of modulating myostatin activity
    Publication number: 20040138118
    Abstract: It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
    Type: Application
    Filed: September 16, 2003
    Publication date: July 15, 2004
    Inventors: Neil Wolfman, Kathy Tomkinson