Patents by Inventor Katia MIELE

Katia MIELE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of midostaurin with high purity
    Patent number: 11939342
    Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: March 26, 2024
    Assignee: PROCOS S.P.A.
    Inventors: Alberto Lena, Antonio Toppino, Katia Miele, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE PURIFICATION OF INDOLE CARBAZOLE ALKALOIDS
    Publication number: 20230128149
    Abstract: Disclosed is a process for the purification of staurosporine (1), which comprises salification of staurosporine (1) (Formula (1)) by treatment with a mineral acid to give a precipitated salt, isolation of the staurosporine (1) precipitated salt, treatment of the staurosporine (1) isolated salt with an organic base, and isolation of staurosporine (1). Also disclosed are novel polymorphic forms of the mono- and bis-hydrochloride salts of staurosporine (1).
    Type: Application
    Filed: March 1, 2021
    Publication date: April 27, 2023
    Applicant: INDENA S.P.A.
    Inventors: Katia Miele, Luca Domenighini, Daniele Ciceri
  • PROCESS FOR THE PREPARATION OF MIDOSTAURIN WITH HIGH PURITY
    Publication number: 20220098216
    Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.
    Type: Application
    Filed: March 25, 2020
    Publication date: March 31, 2022
    Applicant: PROCOS S.P.A.
    Inventors: Alberto LENA, Antonio TOPPINO, Katia MIELE, Jacopo ROLETTO, Paolo PAISSONI