Abstract: The present invention relates to nucleic acid constructs or sets of nucleic acid constructs, which confer resistance to two or more viruses to plants of the genus Beta. The nucleic acid constructs comprise or encode sense and/or antisense sequences targeting a genomic sequence of at least two relevant viruses, which infect Beta plants. The present invention also provides transgenic Beta plants, which are resistant to at least two viruses as well as a method of conferring resistance to a Beta plant to at least two viruses, which comprises the step of transforming a Beta plant cell with a nucleic acid construct or a set of nucleic acid constructs according to the invention.