Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to natural killer (NK) cells. The invention also includes multimeric binding complexes comprising at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands or said multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by natural killer (NK) cells, such as inflammatory disorders, autoimmune disease and cancer.

Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: Introduced here is technology to monitor moisture levels in a hygiene product, such as tampons, pads, menstrual cups, child diapers, adult diapers etc. According to one embodiment, a moisture sensor is inserted inside a feminine hygiene product. The moisture sensor is connected to a wearable device that gathers the moisture data and sends the data to a mobile device, such as a cell phone. The cell phone generates notifications to the user, such as percentage saturation of the feminine hygiene product, message to change the feminine hygiene product, expected start and end dates of the next menstrual cycle, etc. According to another embodiment, the moisture sensor can be inserted in other hygiene products, such as child diapers or adult diapers, to measure the amount of urination, defecation, or other excretions, and to generate notifications to the user, the user's caretaker, or a third party.

Abstract: Introduced here is technology to monitor moisture levels in a hygiene product, such as tampons, pads, menstrual cups, child diapers, adult diapers etc. According to one embodiment, a moisture sensor is inserted inside a feminine hygiene product. The moisture sensor is connected to a wearable device that gathers the moisture data and sends the data to a mobile device, such as a cell phone. The cell phone generates notifications to the user, such as percentage saturation of the feminine hygiene product, message to change the feminine hygiene product, expected start and end dates of the next menstrual cycle, etc. According to another embodiment, the moisture sensor can be inserted in other hygiene products, such as child diapers or adult diapers, to measure the amount of urination, defecation, or other excretions, and to generate notifications to the user, the user's caretaker, or a third party.