Abstract: A system and method for automated production of a viable cell culture on a mesh supported membrane lattice that is suitable for therapeutic implantation in connection with regenerative cell therapy. At least one bioreactor vial is configured to be supported and received by an automated handling and processing system. The bioreactor vial has a reactor well therein into which a mesh-supported submicron parylene-C membrane (MSPM) scaffold is received. Various support fluids are added and subsequently RPE cells are seeded onto the MSPM. The RPE cells form a culture of monolayer of hexagonally shaped RPE cells that is adhered to the MSPM which is suitable for subsequent transplantation into an eye in order to develop in a manner that supports and maintains the photoreceptors of the retina. The system is preferably automated and configured to process multiple bioreactors simultaneously.

Abstract: System and method for maintaining an organ and transporting the organ from a donor to a recipient, maintaining normothermic temperature of the organ. The system includes a circulation system providing oxygenated perfusate to the organ and enabling continuous monitoring of the perfusate moving through the organ. The tank can provide an inlet that can accept selected infusible materials, and an outlet that can enable sampling and waste removal. The system can continually monitor the solution bath in which the organ is bathed, and the system can manage the composition of the gas in the tank.