Patents by Inventor Katie O'CALLAGHAN

Katie O'CALLAGHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CO-USE OF ANTI-BCMA ANTIBODY AND ANTIBODY-COUPLED T CELL RECEPTOR (ACTR) IN CANCER THERAPY AND B CELL DISORDERS
    Publication number: 20190381171
    Abstract: Disclosed herein are methods of enhancing antibody-dependent cell cytotoxicity (ADCC) in a subject comprising administering to a subject in need thereof a therapeutically effective amount of an anti-BCMA antibody and an effective amount of T lymphocytes and/or NK cells expressing an antibody-coupled T-cell receptor (ACTR) construct, which may comprises an extracellular domain with affinity and specific for the Fc portion of an immunoglobulin molecule (Ig); a transmembrane domain; optionally one or more of co-stimulatory domains, and a cytoplasmic signaling domain comprising an immunoreceptor tyrosine-based activation motif (ITAM).
    Type: Application
    Filed: February 16, 2018
    Publication date: December 19, 2019
    Applicant: UNUM THERAPEUTICS INC.
    Inventors: Heather HUET, Seth ETTENBERG, Django SUSSMAN, Tooba CHEEMA, Taylor HICKMAN, Katie O'CALLAGHAN, Maureen RYAN