Patents by Inventor Katie R. Flenker

Katie R. Flenker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGONUCLEOTIDE-BASED PROBES AND METHODS FOR DETECTION OF MICROBES
    Publication number: 20220098648
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Application
    Filed: October 5, 2021
    Publication date: March 31, 2022
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Howswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliott Burghardt, Karen Clark
  • Oligonucleotide-based probes and methods for detection of microbes
    Patent number: 11155882
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Howswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliott Burghardt, Karen Clark
  • OLIGONUCLEOTIDE-BASED PROBES AND METHODS FOR DETECTION OF MICROBES
    Publication number: 20200283830
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Application
    Filed: February 19, 2020
    Publication date: September 10, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Howswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliott Burghardt, Karen Clark
  • Oligonucleotide-based probes for detection of bacterial nucleases
    Patent number: 10653800
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: May 19, 2020
    Assignees: University of Iowa Research Foundation, Integrated DNA Technologies, Inc.
    Inventors: James O. McNamara, II, Katie R. Flenker, Lingyan Huang, Alexander R. Horswill, Mark A. Behlke, Frank J. Hernandez
  • Oligonucleotide-based probes and methods for detection of microbes
    Patent number: 10619219
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: April 14, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Horswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliot Burghardt, Karen Clark
  • OLIGONUCLEOTIDE-BASED PROBES AND METHODS FOR DETECTION OF MICROBES
    Publication number: 20160340717
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Application
    Filed: February 9, 2015
    Publication date: November 24, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Horswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliot Burghardt, Karen Clark
  • OLIGONUCLEOTIDE-BASED PROBES FOR DETECTION OF BACTERIAL NUCLEASES
    Publication number: 20140199245
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful in detection assays. Accordingly, in certain embodiments, the present invention provides a probe for detecting a microbial endonuclease comprising a substrate oligonucleotide of 2-30 nucleotides in length, a fluorescence-reporter group operably linked to the oligonucleotide, and a fluorescence-quencher group operably linked to the oligonucleotide. The fluorescence-reporter group and the fluorescence-quencher group are separated by at least one RNAse-cleavable residue, e.g., RNA base.
    Type: Application
    Filed: August 30, 2012
    Publication date: July 17, 2014
    Applicants: INTEGRATED DNA TECHNOLOGIES, INC., UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, II, Katie R. Flenker, Lingyan Huang, Alexander R. Horswill, Mark A. Behlke, Frank J. Hernandez