Patents by Inventor Katja Brose
Katja Brose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20090155928Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: ApplicationFiled: August 13, 2007Publication date: June 18, 2009Applicant: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
-
Publication number: 20050196783Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: ApplicationFiled: December 23, 2004Publication date: September 8, 2005Applicant: The Regents of the University of CaliforniaInventors: Corey Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
-
Patent number: 6861228Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: November 6, 2002Date of Patent: March 1, 2005Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
-
Publication number: 20030170727Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: ApplicationFiled: November 6, 2002Publication date: September 11, 2003Inventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
-
Patent number: 6270995Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: March 31, 2000Date of Patent: August 7, 2001Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
-
Patent number: 6270984Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: March 31, 2000Date of Patent: August 7, 2001Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
-
Patent number: 6046015Abstract: Disclosed are methods and compositions for identifing agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: November 13, 1998Date of Patent: April 4, 2000Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne