Abstract: Disinfection devices and methods of using the same are described. In embodiments the disinfection devices include a base, a lid, a sanitizing gas supply, a sanitization chamber with an exhaust port and chamber opening, and a fan. When the lid is closed the fan can operate in a first (low flow, high static pressure) flow condition, during which gas may flow through the device at a first (relatively low) flow rate. When the lid is open the fan can operate in a second (high flow, low static pressure) flow condition, during which the fan may exhaust all or substantially all sanitizing gas in the sanitization chamber through the exhaust port over a short exhaust period. The systems and methods can enable a user to rapidly access an article being sanitized with little or no risk of exposure to the sanitizing gas, even when a disinfection operation is in process.