Abstract: Disclosed are neoglycoconjugates and/or glycosides containing glycan selected from Galp?1,3Galf?, Galp?1,6Galp?1,3Galf?, or Galp?1,3Galf?1,3Manp?. Methods of using the glycosides and/or neoglycoconjugates as diagnostic or prognostic biomarkers, vaccines, treating or detecting parasitic diseases, such as cutaneous leishmaniasis are disclosed.

Abstract: Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.

Abstract: Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-?(1,2)-R, Galp-?(1,3)-R, Galp-?(1,4)-R, or Galp-?(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treating Leishmania infections.

Abstract: Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.

Abstract: Certain embodiments are directed to method for synthesizing and using glycoconjugates based on the immunodominant epitope Gal?(1,3)Gal?(1,4)GlcNAc? (Gal?3LN?).

Abstract: Certain embodiments are directed to method for synthesizing and using glycoconjugates based on the immunodominant epitope Gal?(1,3)Gal?(1,4)GlcNAc? (Gal?3LN?).

Abstract: Certain embodiments are directed to method for synthesizing and using glycoconjugates on the immunodominant epitope Gal?(1,3)Gal?(3(1,4)GlcNAc? (Gal?3LN?).

Abstract: A novel 34 amino acid long collagen-like peptide rich in proline, hydroxyproline, and glycine, and with several photoreactive N-acyl-7-nitroindoline units incorporated into the peptide backbone was synthesized by on-resin fragment condensation. The circular dichroism measurement of this peptide supports a stable triple helix structure. This peptide has potential as a new biomimetic material with built-in latent photochemical functions that enable the decomposition into small peptide fragments by illumination with UV light of 350 nm. Using a photoreactive glycine derivative as a model compound for the collagen-like peptide, we demonstrate that its photolysis can also be triggered by a two-photon absorption process using a femtosecond laser at 710 nm. When a thin film of this compound is irradiated with femtosecond laser light at 710 nm the photochemistry occurs only at locations of irradiation.

Abstract: Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-?(1,2)-R, Galp-?(1,3)-R, Galp-?(1,4)-R, or Galp-?(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treating Leishmania infections.

Abstract: Certain embodiments are directed to method for synthesizing and using glycoconjugates on the immunodominant epitope Gal?(1,3)Gal?(3(1,4)GlcNAc? (Gal?3LN?).