Patents by Inventor Katrin Greppmair

Katrin Greppmair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF CALIBRATION DEVIATIONS OF pH-MEASURING DEVICES
    Publication number: 20240132829
    Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured
    Type: Application
    Filed: December 1, 2023
    Publication date: April 25, 2024
    Inventors: Detlef EISENKRAETZER, Christian KLINGER, Katrin GREPPMAIR
  • Identification of calibration deviations of pH-measuring devices
    Patent number: 11866686
    Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: January 9, 2024
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
  • Monitoring state deviations in bioreactors
    Patent number: 11473042
    Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: October 18, 2022
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
  • IDENTIFICATION OF CALIBRATION DEVIATIONS OF pH-MEASURING DEVICES
    Publication number: 20220325223
    Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured
    Type: Application
    Filed: January 13, 2022
    Publication date: October 13, 2022
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
  • Identification of calibration deviations of pH-measuring devices
    Patent number: 11371006
    Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured a
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 28, 2022
    Assignee: Hoffman-La Roche, Inc.
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
  • PROCESS FOR CULTURING MAMMALIAN CELLS
    Publication number: 20200385673
    Abstract: Processes for culturing mammalian cells, and for producing recombinant products expressed by mammalian cells, involving a pH up-shift are provided. The processes are particularly suitable for industrial-scale cell culture, and for culture of cells that produce therapeutic products. The processes comprise a first culture stage, carried out at a first pH, and a second culture stage, carried out at a second pH that is higher than the first pH.
    Type: Application
    Filed: November 29, 2018
    Publication date: December 10, 2020
    Inventors: Katrin GREPPMAIR, Thomas LINK, Zhixin SHAO
  • Monitoring state deviations in bioreactors
    Publication number: 20190367854
    Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.
    Type: Application
    Filed: October 28, 2016
    Publication date: December 5, 2019
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
  • Monitoring state deviations in bioreactors
    Publication number: 20180273885
    Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.
    Type: Application
    Filed: October 28, 2016
    Publication date: September 27, 2018
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
  • Identification of calibration deviations of pH-measuring devices
    Publication number: 20180216059
    Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured a
    Type: Application
    Filed: October 28, 2016
    Publication date: August 2, 2018
    Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair