Patents by Inventor Katrina L. Mealey

Katrina L. Mealey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF HEPATOBILIARY DISEASE AND ASSOCIATED DISORDERS
    Publication number: 20110038944
    Abstract: Provided are nucleic acids comprising ABCB4 gene mutations (e.g., insertions, deletions, frame shift, missense) (e.g., canine ABCB4 1583_1584G) that result in prematurely terminated and/or inactive ABCB4 proteins. A significant association (P=1.54E-7) of the mutations was detected between gallbladder mucoceles-affected dogs, providing methods for detection or diagnosis of a hepatobiliary disease and/or related conditions (e.g., increased mucin secretion, mucinous hyperplasia, gallbladder mucocele, progressive familial intrahepatic cholestasis (type 3), cholelithiasis, primary biliary cirrhosis, and intrahepatic cholestasis of pregnancy). Compositions and methods for genotyping or screening of test subjects are provided, and have added utility in combination with surgical intervention, selective breeding, and medical or dietary management. Also provided are methods of treatment of dogs with hepatobiliary disease, comprising administration of hydrophilic, less cytotoxic bile acids (e.g., ursodeoxycholate).
    Type: Application
    Filed: August 13, 2010
    Publication date: February 17, 2011
    Inventors: KATRINA L. MEALEY, JONATHAN MINCH
  • MDR1 variants and methods for their use
    Patent number: 7776588
    Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: August 17, 2010
    Assignee: Washington State University Research Foundation
    Inventor: Katrina L. Mealey
  • MDR1 VARIANTS AND METHODS FOR THEIR USE
    Publication number: 20080206144
    Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
    Type: Application
    Filed: April 28, 2008
    Publication date: August 28, 2008
    Inventor: Katrina L. Mealey
  • Method of detecting ivermectin sensitivity in a canine subject by identifying a mutation in a MDR1-encoding sequence
    Patent number: 7393643
    Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: July 1, 2008
    Assignee: Washington State University Research Foundation
    Inventor: Katrina L. Mealey
  • Mdr1 variants and methods for their use
    Publication number: 20040265896
    Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
    Type: Application
    Filed: July 21, 2004
    Publication date: December 30, 2004
    Applicant: Washington State University Research Foundation
    Inventors: Katrina L. Mealey, Steven A. Bentjen
  • Method of detecting ivermectin sensitivity in a canine subject by identifying a mutation in a mdr1-encoding sequence
    Patent number: 6790621
    Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: September 14, 2004
    Assignee: Washington State University Research Foundation
    Inventors: Katrina L. Mealey, Steven A. Bentjen
  • Mdr1 variants and methods for their use
    Publication number: 20020177147
    Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
    Type: Application
    Filed: January 10, 2002
    Publication date: November 28, 2002
    Applicant: Washington State University Research Foundation
    Inventors: Katrina L. Mealey, Steven A. Bentjen