Abstract: A device having a biocompatible polymer as a body and regularly spaced radiation seeds and regularly spaced magnetic materials disposed of within the body of the biocompatible polymer, or uniformly distributed liquid radiation and magnetic fluid materials within a polymer slab, hollow thick wall polymer shell, or thin wall polymer balloon, as suitable for surgical placement within a resection cavity for treatment of at-risk tissue in the tumor margin with local hyperthermia in combination with radiation and potentially also with chemotherapy and/or immunotherapy that is slowly released from the biocompatible polymer.

Abstract: A device having a biocompatible polymer as a body and regularly spaced radiation seeds and regularly spaced magnetic materials disposed of within the body of the biocompatible polymer, or uniformly distributed liquid radiation and magnetic fluid materials within a polymer slab, hollow thick wall polymer shell, or thin wall polymer balloon, as suitable for surgical placement within a resection cavity for treatment of at-risk tissue in the tumor margin with local hyperthermia in combination with radiation and potentially also with chemotherapy and/or immunotherapy that is slowly released from the biocompatible polymer.

Abstract: In one aspect, the present invention relates to a new method of treating or osteoarthritis in a mammal in need thereof. In certain embodiments, the method comprises contacting at least one biomimetic proteoglycan with the affected joint of the mammal. The biomimetic proteoglycan comprises a core structure and at least one bristle. The biomimetic proteoglycan resists endogenous enzymatic degradation and integrates with the existing tissue matrix.

Abstract: In one aspect, the present invention relates to a new method of treating or osteoarthritis in a mammal in need thereof. In certain embodiments, the method comprises contacting at least one biomimetic proteoglycan with the affected joint of the mammal. The biomimetic proteoglycan comprises a core structure and at least one bristle. The biomimetic proteoglycan resists endogenous enzymatic degradation and integrates with the existing tissue matrix.

Abstract: The present invention novel methods of preparing biomimetic proteoglycans, such as bottle-brush, chondroitin sulfate-containing, biomimetic proteoglycans. In certain embodiments, the methods of the invention comprise contacting a core polymer comprising at least one acyl chloride group with a GAG comprising a terminal primary amine.

Abstract: The present invention provides hydrogel-based compositions that are suitable for replacing or supplementing the nucleus pulposus in a subject. The compositions of the invention are useful for treating, ameliorating or reverting degradation of the nucleus pulposus in the subject. The present invention also provides methods of preparing and using such compositions.

Abstract: In one aspect, the present invention relates to a new method of treating or preventing urinary incontinence in a mammal in need thereof. In certain embodiments, the method comprises contacting a composition comprising at least one biomimetic proteoglycan with the urethral or periurethral tissue of the mammal.