Abstract: Supernatant of the urinary sample (SP1) was mixed with an acid or alkali and heated (SP2) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP3). Next, using fluorometry, three-dimensional fluorescence spectrum consisted of an excitation light wavelength, fluorescence wavelength and fluorescence intensity (SP4). Then, a relative maximum peak is detected as a specific point in the three-dimensional fluorescence spectrum to specify a specific point attribute (peak number, peak position and fluorescence intensity) and then the urinary sample is sorted based on the attribute (SP5). Finally, the presence or absence of a disease such as a malignant tumor is determined based on the sorting results of the urinary sample (P6).

Abstract: A malignant tumor detection method suitable for the primary screening for a malignant tumor, and a detection kit using the method are provided. Considering various amino group-containing low molecular weight tumor markers in a sample, a tumor marker is labeled under suitable conditions using an amino group labeling dye which reacts specifically with it. The labeled tumor marker is subjected to spectroscopic measurement, and the tumor marker amount present in the sample is calculated. The presence or absence of a malignant tumor is detected by comparing the tumor marker amount with a threshold value for the tumor marker obtained from healthy persons. The series of these steps is performed using the detection kit.

Abstract: A method for detecting hydroxyprolines and a detection kit therefor are provided. A kit for detecting a hydroxyproline comprising a buffering agent or the like that is obtained from the immobilization of 4-chrolo-7-nitrobenzofurazane or 4-fluoro-7-nitrobenzofurazane on a solid phase is used to react with a sample containing a hydroxyproline; and the resultant reaction product is measured for its characteristic fluorescence (or absorption) to selectively detect the hydroxyproline with high sensitivity, rapidness and easiness.

Abstract: The present invention provides a chemiluminescence measuring apparatus which is small in size and high in operability and has a function of performing accurate quantitative analysis and the like. The apparatus includes at least a box-like housing having an opening, a cover provided on a top surface of the housing and having a through hole for introducing a first detachable vessel into the inner space of the housing, a holder having a concave portion and enclosing the opening of the housing, the hollow chamber having an opening at a side wall thereof and partially housing a second vessel, a photo-sensing unit for detecting luminescence from the second vessel via the through hole of the hollow chamber, and a shutter mechanism for intermittently cutting optical path between the photo-sensing unit and the second vessel.

Abstract: An oxidizing composition in the form of powder for oxidizing a chemiluminescent substance, including an oxidizing agent and a binder.

Abstract: The first branch 1a of the optical fiber 1 is connected to the light source 2, and the second branch 1b is connected to the optical measuring unit 3. A taper-shaped tip member 8 is fitted to a tip end of the optical fiber unit 1 with the use of a jig member 4. The inner hollow space 7 in the tip member 8 is connected with the air suction device 11, through the gap 5 formed between the optical fiber unit 1 and the jig member 4 and the air suction tube 10. The air suction device 11 discharges air from the inner hollow space 7 to suck liquid through the through-hole 6 into the inner hollow space. The air suction device 11 is controlled by the controller 12. Because the optical fiber unit can directly irradiate liquid with light, measurement can be performed with high sensitivity. The optical fiber unit is prevented from contamination.

Abstract: A photoactive lanthanide complex of 2,2',2",9,9',9"-bis[nitrilotri(methylene)]tris(1,10-phenanthroline) and its functional derivative capable of bonding with substrate such as polymer and protein are provided. The lanthanide complex is usable for photosynthesis and photoimmunoassay.

Abstract: A particle comprising a magnetic particle is placed in a liquid having a monomolecular film formed on its surface. Then, the particle is pulled up by means of a pair of electromagets facing each other with the air-liquid interface present therebetween so that the particle passes through the interface. As a result, a monomolecular coat is formed on the surface of the particle. A monomolecular built-up coat is formed by repeating the above procedure predetermined times.