Patents by Inventor Katsuharu Iinuma
Katsuharu Iinuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7250389Abstract: Disclosed are novel compounds useful for prevention or control of diseases derived from fungi, a process for producing the same, and novel antifungal agents using the novel compounds. The compounds useful for prevention and treatment of diseases derived from fungi according to the present invention include novel compounds represented by formula (I). The compounds represented by formula (I) have potent antifungal activity against diseases derived from fungi, and do not have phytotoxicity to mammals and agricultural and garden plants, from which diseases should be eliminated, and, even when applied to agricultural and garden plants, have high photostability.Type: GrantFiled: February 8, 1999Date of Patent: July 31, 2007Assignee: Meiji Seika Kaisha, Ltd.Inventors: Osamu Sakanaka, Koichi Mitomo, Takayoshi Tamura, Yasushi Murai, Katsuharu Iinuma, Takeshi Teraoka, Kikuko Kuzuhara, Haruki Mikoshiba, Makoto Taniguchi
-
Patent number: 6486149Abstract: Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.Type: GrantFiled: November 26, 2001Date of Patent: November 26, 2002Assignee: Meiji Seika Kaisha Ltd.Inventors: Masahiro Onodera, Masamichi Sukegawa, Kiyoshi Yasui, Tatsuo Watanabe, Toyomi Sato, Yasushi Murai, Katsuharu Iinuma
-
Patent number: 6441162Abstract: A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving an amorphous form of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous form well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10° C.Type: GrantFiled: May 15, 2001Date of Patent: August 27, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kiyoshi Yasui, Masahiro Onodera, Masamichi Sukegawa, Tatsuo Watanabe, Yuichi Yamamoto, Yasushi Murai, Katsuharu Iinuma
-
Publication number: 20020037322Abstract: Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.Type: ApplicationFiled: November 26, 2001Publication date: March 28, 2002Inventors: Masahiro Onodera, Masamichi Sukegawa, Kiyoshi Yasui, Tatsuo Watanabe, Toyomi Sato, Yasushi Murai, Katsuharu Iinuma
-
Patent number: 6342493Abstract: Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.Type: GrantFiled: July 7, 2000Date of Patent: January 29, 2002Assignee: Meiji Seika Kaisha Ltd.Inventors: Masahiro Onodera, Masamichi Sukegawa, Kiyoshi Yasui, Tatsuo Watanabe, Toyomi Sato, Yasushi Murai, Katsuharu Iinuma
-
Publication number: 20020002279Abstract: A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving an amorphous form of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous form well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10° C.Type: ApplicationFiled: May 15, 2001Publication date: January 3, 2002Inventors: Kiyoshi Yasui, Masahiro Onodera, Masamichi Sukegawa, Tatsuo Watanabe, Yuichi Yamamoto, Yasushi Murai, Katsuharu Iinuma
-
Patent number: 6329338Abstract: Novel derivatives of PF1022 substance, which are cyclodepsipeptides represented by the general formula (I) shown below or their salts are useful as anthelmintic agent for prevention or treatment of parasitic infections.Type: GrantFiled: May 20, 1998Date of Patent: December 11, 2001Assignees: Meiji Seika Kaisha, Ltd., Bayer AktiengesellschaftInventors: Osamu Sakanaka, Yumiko Okada, Makoto Ohyama, Maki Matsumoto, Masaaki Takahashi, Yasushi Murai, Katsuharu Iinuma, Achim Harder, Norbert Mencke, Gerhard Bonse, Peter Jeschke
-
Patent number: 6294669Abstract: As a novel substance is provided such a new, crystalline substance of Cefditoren povoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving amorphous substance of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous substance well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone.Type: GrantFiled: March 19, 1999Date of Patent: September 25, 2001Assignee: Meiji Seika Kaisha Ltd.Inventors: Kiyoshi Yasui, Masahiro Onodera, Masamichi Sukegawa, Tatsuo Watanabe, Yuichi Yamamoto, Yasushi Murai, Katsuharu Iinuma
-
Patent number: 6288223Abstract: There can be produced, at a high selectivity and in a high yield, the Z-isomer of a 7-N-unsubstituted or substituted-amino-3-[2-(4-substituted or unsubstituted-thiazol-5-yl) vinyl]-3-cephem-4-carboxylic acid or an ester thereof having the general formula (IV) wherein R1 denotes a hydrogen atom, a mono-valent amino-protecting group or a 2-(2-N-protected or unprotected aminothiazol-4-yl)- 2-alkoxyiminoacetyl group, R2 denotes a hydrogen atom, or R1 and R2 as taken together mean one di-valent amino-protecting group, R3 denotes a hydrogen atom, pivaloyloxymethyl group or a carboxyl-protecting group and R8 denotes an alkyl group and so on, by a process comprising reacting a 7-N-unsubstituted or substituted-amino-3-[(tri-substituted-phosphoranylidene) methyl]-3-cephem-4-carboxylic acid or an ester thereof having the general formula (I) wherein R1, R2 and R3 each have the same meanings as defined above, and R4 denotes a lower alryl group or an aryl group, withType: GrantFiled: February 18, 2000Date of Patent: September 11, 2001Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yumiko Okada, Masamichi Sukegawa, Tatsuo Watanabe, Hiroyuki Iwasawa, Yasushi Murai, Katsuharu Iinuma
-
Patent number: 6265537Abstract: The present invention relates to cyclic thiodepsipeptides, in particular 18 to 24-membered cyclothiodepsipeptides, their endoparasitical compositions, and methods of making and using the same.Type: GrantFiled: September 27, 1999Date of Patent: July 24, 2001Assignees: Bayer Aktiengesellschaft, Meiji Seika Kaisha, Ltd.Inventors: Peter Jeschke, Achim Harder, Georg von Samson-Himmelstjerna, Norbert Mencke, Gerhard Bonse, Katsuharu Iinuma, Osamu Sakanaka
-
Patent number: 6033879Abstract: The present invention relates to a new process for the preparation of substituted aryllactic acid-containing cyclodepsipeptides having 24 ring atoms of the formula (I): ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 have the meaning given in the description,with the aid of fungal strains of the species Agonomycetales or enzymatic preparations isolated therefrom.Type: GrantFiled: June 4, 1998Date of Patent: March 7, 2000Assignee: Bayer AktiengesellschaftInventors: Peter Jeschke, Gerhard Bonse, Gerhard Thielking, Winfried Etzel, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher, Katsuharu Iinuma, Kouichi Miyamoto
-
Patent number: 5747448Abstract: Novel PF 1022 derivatives--cyclodepsipeptides represented by the below-described formula (I)--and acid addition salts thereof, which have been synthesized according to the present invention, have anthelmintic activities against various parasitic worms which are parasitic on human bodies, domestic animals and pet animals. They are therefore useful as anthelmintics for the prevention or treatment of parasitic infections. ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y and Z have been defined herein.Type: GrantFiled: September 8, 1995Date of Patent: May 5, 1998Assignee: Meiji Seika Kaisha, Ltd.Inventors: Makoto Ohyama, Maki Ohishi, Yumiko Okada, Masao Koyama, Shinjiro Sumi, Yasushi Murai, Masayuki Takagi, Tadaaki Okada, Osamu Sakanaka, Toshio Yoneta, Katsuharu Iinuma, Seiji Shibahara
-
Patent number: 5596096Abstract: New compounds are disclosed having the general formulas (1) and (2): ##STR1## Also described is a process for preparing the compounds of formulas (1) and (2). Further described is a process for preparing a cephalosporin derivative having formula (5): ##STR2## by converting the compound of formula (1) to the compound of formula (2) and then converting the compound of formula (2) to the compound of formula (5).Type: GrantFiled: July 29, 1994Date of Patent: January 21, 1997Assignee: Meiji Seika Kaisha, Ltd.Inventors: Osamu Sakanaka, Shouhei Yasuda, Shinjiro Sumi, Katsufumi Sebata, Katsuharu Iinuma, Ken Nishihata
-
Patent number: 5405955Abstract: New compounds are disclosed having the general formulas (1) and (2): ##STR1## Also described is a process for preparing the compounds of formulas (1) and (2). Further described is a process for preparing a cephalosporin derivative having formula (5): ##STR2## by converting the compound of formula (1) to the compound of formula (2) and then converting the compound of formula (2) to the compound of formula (5).Type: GrantFiled: June 14, 1993Date of Patent: April 11, 1995Assignee: Meiji Seika Kaisha, Ltd.Inventors: Osamu Sakanaka, Shouhei Yasuda, Shinjiro Sumi, Katsufumi Sebata, Katsuharu Iinuma, Ken Nishihata
-
Patent number: 5268168Abstract: An antibacterial and deodorant processing agent for the sanitary processing, in particular, for the sanitary processing of a fiber material having a hydrophobic surface, which comprises a derivative of an aminoglycoside antibiotic, and a method for the antibacterial and deodorant processing of a fiber material having a hydrophobic surface with the use of said antibacterial and deodorant processing agent.Type: GrantFiled: February 14, 1991Date of Patent: December 7, 1993Assignees: Sakai Engineering Co., Ltd., Meiji Seika Kaisha, Ltd.Inventors: Matsuko Katayama, Kimiaki Yasuda, Hidehi Takebe, Katsuharu Iinuma, Toshio Yoneta
-
Patent number: 4555404Abstract: Sodium 7.beta.-(2D-2-amino-2-carboxyethylthioacetamido)-7.alpha.-methoxy-3-(1-met hyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate heptahydrate and a method of obtaining it from the corresponding carboxylate.Type: GrantFiled: May 16, 1983Date of Patent: November 26, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Ken Nishihata, Katsuharu Iinuma, Hitoshi Yamada, Fumiya Hirano, Takashi Tsuruoka