Abstract: The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (2) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (3) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals.

Abstract: The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (2) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (3) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals.

Abstract: [PROBLEM] To provide a novel star polymer useful as resist materials with high sensitivity and high resolution, and a novel coupling agent for anionic polymerization for synthesizing the polymer. [MEANS FOR SOLVING THE PROBLEM] A star polymer comprising: a core part derived from a coupling agent for anionic polymerization composed of an acid-degradable compound having an organic group derived from a halide; and an arm part that is attached to the core part and composed of an acid-degradable polymer chain obtained by anionic polymerization; and the coupling agent for anionic polymerization.

Abstract: [PROBLEM] To provide a novel star polymer useful as resist materials with high sensitivity and high resolution, and a novel coupling agent for anionic polymerization for synthesizing the polymer. [MEANS FOR SOLVING THE PROBLEM] A star polymer comprising: a core part derived from a coupling agent for anionic polymerization composed of an acid-degradable compound having an organic group derived from a halide; and an arm part that is attached to the core part and composed of an acid-degradable polymer chain obtained by anionic polymerization; and the coupling agent for anionic polymerization.

Abstract: This invention has been realized in order to obtain green compacts of a fixed height by pressure molding of material powder with a fixed gap between upper and lower punches. A powder compacting method of this invention performs a punch driving step wherein, after filling material powder in a cavity, the material powder filled in the cavity is pressure molded by using an upper punch and a lower punch, said punch driving step comprising a primary driving step of driving either one of the punches until the thickness of the cavity formed between the upper and lower punches becomes slightly greater than a target molding thickness, and a secondary driving step of measuring a gap between the upper and lower punches and driving either one of the punches while controlling it until the measured value reaches the target molding thickness.

Abstract: A brazed sintered compact composed of first and second components, which are easily positioned relative to each other, enabling the provision of a good joining clearance. If a protrusion 3 of a first component 1 is fitted into a recess 13 of a second component 10, both components are able to be positioned relative to each other. Simultaneously, a joining clearance A can be easily obtained between a joining surface 2 of the first component 1 and a joining surface 12 of the second component 10, corresponding to a dimensional difference therebetween. Also, an inner side surface 4a of a storage groove 4 is aligned with a right or left end 11a of a leg 11, disposed opposite to the inner side surface 4a. Accordingly, it is possible to allow as much brazing material as properly needed to permeate between the joining surfaces 2 and 12. Further, as the surface tension of the surplus brazing material becomes unlikely to be developed in the storage grooves 4,4?, the backflow of the material is prevented.

Abstract: A brazed sintered compact composed of first and second components, which are easily positioned relative to each other, enabling the provision of a good joining clearance. If a protrusion 3 of a first component 1 is fitted into a recess 13 of a second component 10, both components are able to be positioned relative to each other. Simultaneously, a joining clearance A can be easily obtained between a joining surface 2 of the first component 1 and a joining surface 12 of the second component 10, corresponding to a dimensional difference therebetween. Also, an inner side surface 4a of a storage groove 4 is aligned with a right or left end 11a of a leg 11, disposed opposite to the inner side surface 4a. Accordingly, it is possible to allow as much brazing material as properly needed to permeate between the joining surfaces 2 and 12. Further, as the surface tension of the surplus brazing material becomes unlikely to be developed in the storage grooves 4, 4′, the backflow of the material is prevented.

Abstract: A cation exchanger or a chelating agent having at least structural units represented by the following formula (I), the structural units being derived from a crosslinkable monomer containing an unsaturated hydrocarbon group: wherein A represents a C3-C8 alkylene group or a C4-C9 alkoxymethylene group; L represents SO3−X+, where X+ is a counter ion coordinated with the SO3− group, or a chelate-forming functional group; and the benzene ring may be substituted with an alkyl group or a halogen atom.

Abstract: The present invention relates to a process for producing pure water having a total organic carbon content of not more than 200 ppb instantly after start of the operation of a high purity water system, comprising using as an ion exchange resin a specific strongly basic anion exchange resin and passing raw water through the high purity water system at a space velocity of not less than 20. The produced pure water is capable of producing tasteless and odorless pure water instantly after start of the operation of the high purity water system.

Abstract: The invention provides a solid preparation having a quick and pH-independent dissolution with an excellent bioavailability for a drug that is otherwise sharply depressed in solubility with pH elevation. This solid preparation contains granules each comprising a fine particulate core coated with a solid solution comprising a drug which is pH-dependent in solubility and may be released from an enteric base-containing composition at low pH and an enteric base.

Abstract: A coated preparation prepared by coating drug particles having a disagreeable taste with a mixture comprising a hydrophobic substance with a melting point of 45.degree. to 90.degree. C. and a surfactant with a lower melting point and heat treating the coating layer at a temperature ranging from around the melting point of the surfactant up to the melting point of the hydrophobic substance to modify the nature of the coating layer. This preparation can release the drug quickly which sufficiently suppressing the disagreeable taste.

Abstract: A TiCN-based cermet cutting insert superior in toughness with improved wear resistance includes a binding phase and at least two hard dispersion phases. One of the hard dispersion phases includes one of a duplex and triplex structure having a core structure containing at least one of titanium carbonitride and a carbonitride solid solution of Ti and one of a V, Cr, Ti, Nb, Zr, W and Mo (hereinafter referred to as a (Ti,M)CN. The other hard dispersion phase includes a single structure wherein the core structure is composed of at least one of (Ti,M)CN or (Ti,M)CN and TiCN.

Abstract: A TiCN-based cermet cutting insert superior in toughness with improved wear resistance includes a binding phase and at least two of four hard dispersion phases. One of the two hard dispersion phases includes at least one of a duplex or triplex phase structure with a core of a composite carbonitride solid solution and a single-phase structure of a composite carbonitride solid solution. The other hard dispersion phase includes one of a hard dispersion phase of titanium carbonitride and a hard dispersion phase which includes a single-phase structure of titanium carbonitride.

Abstract: A novel nifedipine-containing solid pharmaceutical preparation composition comprising a mixture of nifedipine and at least one 1st(a) substance selected from polyvinyl pyrrolidone, methyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose; a mixture of nifedipine, at least one 1st(b) substance selected from polyvinyl pyrrolidone, urea, citric acid mannitol, succinic acid, methyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose and amino acid, and at least one 2nd substance selected from a surface active agent, polyethylene glycol, propylene glycol, glycerol, a glycerol fatty acid ester and a vegetable oil; or a mixture of nifedipine, the 1st(b) substance, the 2nd substance and calcium lactate.The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered.