Abstract: A control method and a control device for controlling a spark-ignition internal combustion engine that is equipped with a turbocharger and an exhaust gas recirculation device. The operation of the engine is carried out to perform a stoichiometric air-fuel ratio by performing exhaust gas recirculation even in a high-load range including a maximum-output operation point. When the maximum output operation point is required, intake air information such as atmospheric pressure and outside air temperature is used as a basis to calculate intake air density, which is compared with a predetermined density threshold. When the intake density is equal to or less than the density threshold at a high-altitude location or the like, an exhaust gas recirculation rate is set to 0. As a result, the maximum output can be higher than when exhaust gas recirculation is performed.

Abstract: A control method and a control device for controlling a spark-ignition internal combustion engine that is equipped with a turbocharger and an exhaust gas recirculation device. The operation of the engine is carried out to perform a stoichiometric air-fuel ratio by performing exhaust gas recirculation even in a high-load range including a maximum-output operation point. When the maximum output operation point is required, intake air information such as atmospheric pressure and outside air temperature is used as a basis to calculate intake air density, which is compared with a predetermined density threshold. When the intake density is equal to or less than the density threshold at a high-altitude location or the like, an exhaust gas recirculation rate is set to 0. As a result, the maximum output can be higher than when exhaust gas recirculation is performed.

Abstract: Provided is a structure including a first member (2); a second member (3) disposed opposite to the first member (2); and a glass layer (4) disposed between the first member (2) and the second member (3) so as to bond the first member (2) and the second member (3). A glass transition point of the glass layer (4) is lower than a temperature of the glass layer (4) under operation. In the glass layer (4), at least either of ceramic and metallic particles 4b, 4c is dispersed. In a temperature region lower than the glass transition point of the glass layer (4), a thermal expansion coefficient thereof falls in between thermal expansion coefficients of the first member (2) and the second member (3). This allows thermal strain caused within the structure (1) to be reduced when the structure (1) is operated at a higher temperature than a room temperature.

Abstract: Provided is a structure including a first member (2); a second member (3) disposed opposite to the first member (2); and a glass layer (4) disposed between the first member (2) and the second member (3) so as to bond the first member (2) and the second member (3). A glass transition point of the glass layer (4) is lower than a temperature of the glass layer (4) under operation. In the glass layer (4), at least either of ceramic and metallic particles 4b, 4c is dispersed. In a temperature region lower than the glass transition point of the glass layer (4), a thermal expansion coefficient thereof falls in between thermal expansion coefficients of the first member (2) and the second member (3). This allows thermal strain caused within the structure (1) to be reduced when the structure (1) is operated at a higher temperature than a room temperature.

Abstract: Provided are an atmospheric corrosion test procedure and an apparatus used for the test. The procedure involves a salt spray step for supplying salt content containing chloride ions on the surfaces of test pieces placed in a thermo-humidistat chamber and a subsequent dry-wet cyclic step including a dry sub-step for drying the surface of the test pieces in the thermo-humidistat chamber at a low relative humidity and a subsequent wet sub-step at a higher relative humidity than that in the dry sub-step, which are cycled. The salt content is supplied by spraying the salt water in the salt spray step. An exhaust step for removing the salt mist sprayed inside thermo-humidistat chamber is further inserted between the salt deposition step and the dry sub-step. The quantity of the salt content deposited on the surfaces of the test pieces is controlled by adjusting the quantity of the sprayed salt water.

Abstract: Provided is high corrosion resistant equipment for a plant having the lining structure which exhibits high reliability against breaking of a joining portion over a long use period. The high corrosion resistant equipment for a plant includes a lining plate and a support portion which are made of a high corrosion resistance material and a structural material portion made of a steel material or the like. The lining plate and the support portion include a joining portion to which friction stirring is applied. The support portion is assembled into or fastened to the structural material portion by means of the geometrical structure with a gap interposed between the support portion and the structural material portion. Due to such a constitution, high corrosion resistant equipment for a plant having the lining which exhibits high reliability can be acquired.

Abstract: Provided is high corrosion resistant equipment for a plant having the lining structure which exhibits high reliability against breaking of a joining portion over a long use period. The high corrosion resistant equipment for a plant includes a lining plate and a support portion which are made of a high corrosion resistance material and a structural material portion made of a steel material or the like. The lining plate and the support portion include a joining portion to which friction stirring is applied. The support portion is assembled into or fastened to the structural material portion by means of the geometrical structure with a gap interposed between the support portion and the structural material portion. Due to such a constitution, high corrosion resistant equipment for a plant having the lining which exhibits high reliability can be acquired.

Abstract: The present invention provides a virus or a viral vector capable of expressing a gene specifically in a cell having replication ability in a hypoxic state such as a cancer stem cell and injuring the cell, and a pharmaceutical composition comprising the same. Specifically, the present invention provides a virus or a viral vector which comprises a gene encoding a fusion protein of an ODD and a protein essentially required for viral proliferation, and a pharmaceutical composition comprising the same.

Abstract: The present invention provides a virus or a viral vector capable of expressing a gene specifically in a cell having replication ability in a hypoxic state such as a cancer stem cell and injuring the cell, and pharmaceutical composition comprising the same. Specifically, the present invention provides a virus or a viral vector which comprises a gene encoding a fusion protein of an ODD and a protein essentially required for viral proliferation, and a pharmaceutical composition comprising the same.

Abstract: The present invention provides a cell-specific expression/replication vector, and a method of treatment comprising introducing a cell-specific expression/replication vector into specific cells such as malignant tumors in order to selectively disrupt the specific cells. A vector according to the invention is constructed by: obtaining a transcriptional initiation regulatory region of human calponin gene that is specifically expressed in smooth muscle cell; linking the above region upstream to a replication-related gene of a virus such as ICP4 and the like; linking DNA that encodes a protein such as suppressive factor for tumor angiogenesis or apoptosis-related factors and the like via IRES to the replication-related gene of the virus; and integrating a thymidine kinase gene in an intact state into the viral DNA.

Abstract: The present invention provides a cell-specific replication-competent vector system, which does not target normal cells. The vector system is constructed by linking a transcriptional initiation regulatory promoter region upstream of a viral replication-related gene that integrates the linked region into a viral DNA vector. The constructed vector, when introduced into malignant tumor cells, selectively injures only tumor cells or proliferating smooth muscle cells of tumor neovascular tissue due to the selective expression of the regulatory promoter region upstream of a viral replication-related gene. In particular, the present invention relates to a transcriptional initiation regulatory region of the human calponin gene that can selectively express in tumor cells or proliferating smooth muscle cells of tumor neovascular tissue.

Abstract: The present invention provides an effective therapeutic composition for malignant mesothelioma. Specifically, the present invention provides a therapeutic composition for mesothelioma, comprising a calponin-targeting and tumor-lysing variant of herpes simplex virus (HSV-1), preferably a strain d12.CALPf?RR. The present invention further provides a method for generating a cell for treating mesothelioma, which comprises infecting mesothelioma cells removed from a patient with an F-type variant of herpes simplex virus proliferating with targeting a calponin gene, preferably a strain d12.CALPf?RR. Also provided are a cell obtainable by the method, and a calponin-targeting and tumor-lysing variant of herpes simplex virus (HSV-1), preferably a strain d12.CALPf?RR.

Abstract: The present invention is to provide a method wherein a cell-specific expression/replication vector that express and replicate a gene specifically in specific cells such as malignant tumors and the like and does not injure normal cells, particularly a vector that can suppress the expression/replication at a desired period after the expression/replication is constructed, for the use in therapies for such as malignant tumors and the like, and treatment is conducted by introducing the vector to a particular living cell such as malignant tumor and the like for expression.

Abstract: The present invention provides a method for constructing a vector which expresses and replicates a gene specifically to particular cells; a DNA having a gene expression regulatory activity used for its construction; and further, a treatment method comprising the steps of introducing said vector into particular living tissues or cells such as malignant tumors and the like, and said vector expressing and replicating a gene. A cell-specific replication-competent vector which does not act to normal cells in an adult body is constructed by obtaining a transcriptional initiation regulatory region of human calponin gene which is expressed specifically in cells; by linking it upstream of a viral replication-related gene; and by integrating it into a virus DNA. Said constructed cell-specific replication-competent vector is introduced into malignant tumor cells to selectively injure tumor cells or proliferating smooth muscle cells of tumor neovascular.

Abstract: The present invention relates to recombinant DNA comprising DNA coding for smooth-muscle-type myosin heavy chain SM1 isoform protein inserted into vector DNA, a microorganism carrying the recombinant DNA, and an agent for treatment of arteriosclerosis comprising the recombinant DNA. The recombinant DNA of the present invention can be used effectively as an agent for gene therapy of restenosis after PTCA treatment.

Abstract: For producing a plastic film having a plastic fastener, with male and female interlockable profiles, and accessory strips, such as ribs and strips, in preparation of a reclosable plastic bag, there is provided a first forming die which extrudes the accessory strips, a separate second forming die which extrudes the fastener, a pair of nip rolls for press-bonding the accessory strips onto the surface of the film being fed in the vicinity of the first forming die, and a bonding roll for receiving the film with press-bonded accessory strips and the fastener from the second forming die placed onto the film surface such that the fastener is bonded to the surface of the film at the bonding roll by virtue of heat.

Abstract: For producing a plastic film having a plastic fastener, with male and female interlockable profiles, and accessory strips, such as ribs and strips, in preparation of a reclosable plastic bag, there is provided a first forming die which extrudes the accessory strips, a separate second forming die which extrudes the fastener, a pair of nip rolls for press-bonding the accessory strips onto the surface of the film being fed in the vicinity of the first forming die, and a bonding roll for receiving the film with press-bonded accessory strips and the fastener from the second forming die placed onto the film surface such that the fastener is bonded to the surface of the film at the bonding roll by virtue of heat.

Abstract: A method of an apparatus for joining plastic fastener strip continuously to a film. The film of substantial width is run continuously longitudinally through a joining station. A selected longitudinal area of the film is maintained in a stable tensioned condition relative to the remainder of the film as it runs through the joining station. In the joining station, there is joined and secured to the tensioned area a fastener strip running in the same direction and at the same speed as the film. The selected area tensioning is effected by maintaining such area offset relative to the remainder of the film. Downstream from the joining station the film and fastener strip assembly is progressively conditioned until thoroughly stabilized.