Patents by Inventor Katsuichi Shuto
Katsuichi Shuto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5413997Abstract: A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.Type: GrantFiled: January 21, 1993Date of Patent: May 9, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Iwao Kinoshita, Daisuke Machii, Yasuo Onoda, Haruki Takai, Nobuo Kosaka, Katsuichi Shuto, Katsushige Gomi, Makoto Morimoto, Akio Ishii
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Patent number: 5319085Abstract: Quinoline derivatives represented by formula (I): ##STR1## wherein A-B-D represents --C(COO--Y).dbd.CH--C(OR).dbd. (wherein Y represents 8-methyl-8-azabicyclo[3.2.1]oct-3-yl group and R represents alkyl) or --C(OH).dbd.C(COX--Y)--CH.dbd. (wherein X represents --O-- or --NH--; and Y has the same meaning as described above), or a pharmaceutically acceptable salt thereof, possess potent 5HT.sub.3 antagonizing activity and are useful as antiemetic agents.Type: GrantFiled: April 16, 1993Date of Patent: June 7, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Hiroaki Hayashi, Yoshikazu Miwa, Takeshi Kuroda, Akio Ishii, Shunji Ichikawa, Ichiro Miki, Katsuichi Shuto
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Patent number: 5173492Abstract: There are disclosed s-triazolo[3,4-i]purine derivatives represented by formula: ##STR1## wherein Y-Z represents ##STR2## R.sub.4 represents hydrogen, alkyl, substituted or unsubstituted aromatic heterocyclic group or substituted or unsubstituted aryl; and X.sup.2 represents oxygen, sulfur or NH; each of R.sup.1 and R.sup.2 independently represents hydrogen, alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; R.sup.3 represents alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; X.sup.1 represents oxygen or sulfur; and represents a single bond or a double bond or pharmaceutically acceptable salts thereof.Type: GrantFiled: August 23, 1991Date of Patent: December 22, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Junichi Shimada, Kenji Ohmori, Haruhiko Manabe, Kazuihiro Kubo, Akira Karasawa, Tetsuji Ohno, Shizuo Shiozaki, Akio Ishii, Katsuichi Shuto
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Patent number: 5116863Abstract: Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.Type: GrantFiled: March 2, 1987Date of Patent: May 26, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Etsuo Oshima, Toshiaki Kumazawa, Shizuo Otaki, Hiroyuki Obase, Kenji Ohmori, Hidee Ishii, Haruhiko Manabe, Tadafumi Tamura, Katsuichi Shuto
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Patent number: 5112867Abstract: A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits born absorption inhibiting effects and is useful as a medicament for treating osteoporosis.Type: GrantFiled: April 27, 1990Date of Patent: May 12, 1992Assignee: Kyowa Hakko Gogyo Co., Ltd.Inventors: Iwao Kinoshita, Daisuke Machii, Yasuo Onoda, Haruki Takai, Nobuo Kasaka, Katsuichi Shuto, Katsushige Gomi, Makoto Morimoto, Akio Ishii
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Patent number: 5075301Abstract: A furan derivative and a pharmaceutically acceptable salt thereof having gastrointestinal enterokinetic activity which is expected to be used in a broad spectrum of diseases associated with gastrointestinal dyskinesia.Type: GrantFiled: August 14, 1990Date of Patent: December 24, 1991Assignee: Kyowa Hakko Kogyo, Co., Ltd.Inventors: Setsuya Sasho, Shunji Ichikawa, Hiromasa Kato, Hiroyuki Obase, Katsuichi Shuto, Yoshimasa Oiji
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Patent number: 5011824Abstract: A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.Type: GrantFiled: November 13, 1989Date of Patent: April 30, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tomoaki Masada, Yasuhiko Ueno, Eiji Hayakawa, Hirotake Naganuma, Mitsuru Terajima, Tokuyuki Kuroda, Katsuichi Shuto, Shunji Ichikawa
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Patent number: 4952576Abstract: Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.Type: GrantFiled: July 22, 1988Date of Patent: August 28, 1990Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Toru Yasuzawa, Hiroshi Sano, Hirofumi Nakano, Shunji Ichikawa, Katsuichi Shuto
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Patent number: 4914198Abstract: Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##Type: GrantFiled: December 29, 1986Date of Patent: April 3, 1990Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hirofumi Nakano, Mitsunobu Hara, Yoshinori Yamashita, Isao Kawamoto, Katsuhiko Ando, Hiroshi Sano, Toru Yasuzawa, Katsuichi Shuto
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Patent number: 4851414Abstract: Disclosed are anti-dementia agents comprising an antiamnestically effective amount of a benzylpyridine derivative of the formula ##STR1## wherein R is an alkyl group. The invention also pertains to the treatment of dementia by administration of such anti-dementia agent.Type: GrantFiled: August 8, 1988Date of Patent: July 25, 1989Assignee: Kyowa Hakko Kagyo Co., Ltd.Inventors: Shizuo Shiozaki, Katsuichi Shuto, Yoshimasa Oiji
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Patent number: 4683220Abstract: Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.Type: GrantFiled: September 26, 1986Date of Patent: July 28, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Masayuki Yamato, Hiroshi Kase, Isao Kawamoto, Masaji Kasai, Kunikatsu Shirahata, Takashi Deguchi, Katsuichi Shuto, Akira Karasawa, Ryo Okachi, Kiyoshi Nakayama
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Patent number: 4677125Abstract: Phosphorus-containing oligopeptide derivatives are prepared by synthetic methods. The compounds exhibit angiotensin converting enzyme-inhibiting action and are, therefore, useful as anti-hypertensive agents.Type: GrantFiled: August 29, 1986Date of Patent: June 30, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Masayuki Teranishi, Mitsuru Takahashi, Hisayo Nomoto, Hiroshi Kase, Katsuichi Shuto, Kazuhiro Kubo, Akira Karasawa
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Patent number: 4657916Abstract: A quinoline-N-oxide derivative represented by the formula: ##STR1## wherein X is hydroxy, lower alkoxy, lower alkylthio, unsubstituted or substituted aralkyloxy, or unsubstituted or substituted aralkylthio; Y is a hydrogen atom or halogen atom; R.sub.1 is alkylene or alkenylene having 3 to 15 carbon atom; Z is hydroxymethyl, lower alkoxymethyl, unsubstituted or substituted aryloxymethyl, tetrahydropyranyloxymethyl, tetrahydrofuranyloxymethyl, unsubstituted or substituted arylsulfonyloxymethyl, lower alkylthiomethyl, unsubstituted or substituted arylthiomethyl, lower alkylsulfinylmethyl, unsubstituted or substituted arylsulfinylmethyl, lower alkylsulfonylmethyl, unsubstituted or substituted arylsulfonylmethyl, aminomethyl, --CH.sub.2 NHR.sub.2 (wherein R.sub.2 is lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 NR.sub.3 R.sub.4 (wherein R.sub.3 and R.sub.4 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.Type: GrantFiled: September 5, 1985Date of Patent: April 14, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Masayuki Teranishi, Koji Suzuki, Hiroshi Kase, Shigeto Kitamura, Katsuichi Shuto, Kenji Omori
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Patent number: 4618613Abstract: A preventive and healing composition for diseases due to lipoxygenase metabolic products, which comprises an effective amount of a compound represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 15 carbon atoms and at least one pharmaceutically acceptable carrier.Type: GrantFiled: June 28, 1985Date of Patent: October 21, 1986Assignee: Kyowa Hakko Kogyo Company, Ltd.Inventors: Kazuko Hashizume, Hiroshi Kase, Shigeto Kitamura, Takao Iida, Kunikatsu Shirahata, Kenji Omori, Katsuichi Shuto
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Patent number: 4596804Abstract: A dibenz[b,e]oxepin compound having an antiallergic activity is represented by the following general formula: ##STR1## wherein R.sub.1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or --CO.sub.2 R.sub.3 wherein R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R.sub.2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or --X--(CH.sub.2).sub.n --NR.sub.4 R.sub.5 wherein X represents --NH--, --S -- or --O--, R.sub.4 and R.sub.5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.Type: GrantFiled: June 26, 1984Date of Patent: June 24, 1986Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kenji Ohmori, Katsuichi Shuto
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Patent number: 4588729Abstract: Offered is an anticonvulsive composition which comprises an effective amount of a dihydrouracil derivative represented by the formula: ##STR1## [wherein one of A and B is ##STR2## (wherein Y.sub.1, Y.sub.2 and Y.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms, nitro groups, amino groups, carboxyl groups, lower alkoxycarbonyl groups or trifluoromethyl groups), a naphthyl group or a diphenylmethyl group, and the other is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclopentyl group, a cyclohexyl group or ##STR3## (wherein Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms or trifluoromethyl groups), R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or lower alkyl groups, and X is an oxygen atom or a sulfur atom] and at least one pharmaceutically acceptable carrier.Type: GrantFiled: May 16, 1985Date of Patent: May 13, 1986Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Masayuki Teranishi, Chikara Murakata, Ikuo Matsukuma, Katsuichi Shuto, Shunji Ichikawa
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Patent number: 4555402Abstract: A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.Type: GrantFiled: August 10, 1984Date of Patent: November 26, 1985Assignee: Kyowa Hakko Kogyo Co. Ltd.Inventors: Yuzuru Matsuda, Kazuyuki Iwahashi, Takao Iida, Noriaki Hirayama, Kozo Asano, Katsuichi Shuto, Koji Yamada, Kunikatsu Shirahata, Hiroshi Kase
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Patent number: 4547496Abstract: A novel [1] benzepino[3,4-b]pyridine derivative having antiulcer activity is represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group, a halogenated alkyl group, an alkoxy group or a halogen atom; R.sup.2 represents ##STR2## wherein Y represents an amino group, a substituted amino group, a heterocyclic group or a substituted heterocyclic group; Z represents a hydrogen atom, an alkyl group or an acyl group; and m is an integer of 1-3, ##STR3## wherein Z' represents a hydrogen atom or an alkyl group; Y has the same meaning as defined above, and n is 0, 1 or 2; or ##STR4## wherein Z and n have the same meanings as defined above; X represents an oxygen atom or a sulfur atom. Also disclosed are pharmaceutically acceptable acid addition salts of the compound represented by the formula (I).Type: GrantFiled: June 21, 1984Date of Patent: October 15, 1985Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Kumazawa, Yoshimasa Oiji, Hiroshi Tanaka, Katsuichi Shuto
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Patent number: 4138485Abstract: This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.Type: GrantFiled: February 24, 1977Date of Patent: February 6, 1979Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Nobuhiro Nakamizo, Masayuki Teranishi, Ikuo Matsukuma, Katsuichi Shuto, Koji Yamada