Abstract: A method of processing skin surface observation measuring data which is able to address various sicknesses and reduce an error in sickness detection, and a measuring apparatus requiring no filter. The measuring apparatus an irradiator applying a white light to a biological surface as a sample, a detector detecting the spectra of the white light reflected off a plurality of positions on the biological surface, a plotter plotting the absorbances of the above spectra to a light spectrum multi-dimensional space, an analyzer subjecting data in the spectrum multi-dimension space obtained from the plurality of positions to multivariate analysis to determine the eigenvectors of at least first, second and third principal components, and a display projecting data at respective positions in respective eigenvector directions to display their magnitudes on a two-dimension display screen on a gray scale or in colors corresponding to the magnitudes; and a measuring method by the apparatus.

Abstract: An apparatus for measuring a glucose concentration is noninvasive, accurate, and compact. The apparatus includes a detection unit (10) and a principal component analysis (PCA) unit (20). The detection unit includes a light source (11) to emit mid-infrared light, an ATR prism (12) to receive the mid-infrared light with a measuring object placed on the ATR prism, and a spectrum detector (13) to detect an absorption spectrum from the mid-infrared light from the ATR prism. The PCA unit includes a loading memory (24) to store a glucose corresponding loading and a personal data memory (28) to store personal data in the form of a calibration curve. According to the detected absorption spectrum, stored loading, and stored personal data, the PCA unit computes a glucose concentration of the measuring object.

Abstract: A method of processing skin surface observation measuring data able to address various sicknesses and reduce an error in sickness detection, and a measuring apparatus requiring no filter with a simple structure. The measuring apparatus comprises a means of applying a white light to a biological surface as a sample, a means of detecting the spectra of the white light reflected off a plurality of positions on the biological surface, a means of plotting the absorbances of the above spectra to a light spectrum multi-dimensional space, a means of subjecting data in the spectrum multi-dimension space obtained from the plurality of positions to multivariate analysis to determine the eigenvectors of at least first, second and third principal components, and a means of projecting data at respective positions in respective eigenvector directions to display their magnitudes on a two-dimension display screen on a gray scale or in colors corresponding to the magnitudes; and a measuring method by the apparatus.

Abstract: A Raman probe for measuring Raman spectrum includes an exciting-end light guiding path for guiding excitation light from a light source to a sample; a receiving light-guide path for guiding a light signal from said sample to a detector; a band-pass filter for passing said excitation light and blocking Raman-scattered light produced from said exciting-end light guiding path; a pipe for securing said band-pass filter inside said pipe, said pipe being mounted on a light-outgoing end of said exciting-end light guiding path; and an edge filter mounted on a light-incident end of said receiving light-guide path, said edge filter passing Raman-scattered light from said sample while blocking the excitation light. The edge filter is a short-wavelength transmitting filter that permits passage of wavelengths shorter than the excitation wavelength.

Abstract: A Raman probe that can be used with high-intensity excitation light without producing light that interferes with the measurement of Raman scattering. A receiving-end filter is doughnut-shaped, with an exciting-end filter disposed at the center thereof. A light-blocking structure is provided between the exciting-end filter and the receiving-end filter such that the excitation end and the receiving end are completely separated.

Abstract: In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

Abstract: An analysis system comprises an endoscope 10 insertable into the vessel and a Raman analysis apparatus 40. An insert cable 54 of the Raman analysis apparatus 40 is inserted into a channel 10a of the endoscope 10. An excitation optical fiber 60 and a bundle 70A of a plural number of light receivingoptical fibers 70 are received in the insert cable 54. A transparent small piece 63 having a film-like excitation optical filter 64 is abutted against the distal end of the fiber 60. A transparent plate 71 having a film-like light reciving optical filter 72 is abutted against the distal end of fibers bundle 70A. The plate 71 has a center hole 71a and the piece 63 is fitted into the hole 71a.

Abstract: A Raman probe that does not produce Raman scattering that interferes with measurement, and a Raman spectrum measuring apparatus utilizing the Raman probe. The Raman probe comprises a hollow wave-guide path 10 with a light-transmitting medium (core) that is evacuated or filled with a gas that does not produce Raman scattering, such as air.

Abstract: A hollow optical fiber 10 has an intermed ate dielectric layer 12 interposed between an inner periphery side dielectric layer 11 facing a hollow core portion 10a and a metal layer 13. The inner periphery side dielectric layer 11 is formed of calcium fluoride. The intermediate dielectric layer 12 is formed of yttrium fluoride. Metal of the metal layer 13 can be prevented from dispersing into the dielectric layers 12, 11 by the intermediate dielectric layer 12 formed of yttrium fluoride. The hollow optical fiber 10 is manufactured by vapor depositing calcium fluoride on an outer peripheral surface of an acid-soluble glass tube 20 (base material), then vapor depositing yttrium fluoride on its outer peripheral surface, then vapor depositing a metal layer formed of silver, gold or the like on its outer peripheral surface, and thereafter, dissolving the glass tube 20 with acid.

Abstract: As a novel photochemotherapeutical method for the treatment or prevention of an auto-immune disease, there is provided a method for treating an auto-immune disease, which comprises administering to the patient mono-L-aspartyl chlorin e6 or mono-L-glutamyl chlorin e6 or a pharmacologically acceptable salt thereof, followed by subjecting the blood vessel blood of the patient containing the administered compound to exposure with an ultraviolet ray or a laser light, thereby to excite said compound photochemically. This method is effective to decrease the level of auto-antibody in the blood of the patient and is also of high safety.

Abstract: This invention relates to a method for diagnosing insulin-dependent diabetes mellitus, which comprises administering to a mammal such a photosensitizer or an X-ray absorbing substance that has a property capable of accumulating specifically in the macrophages having infiltrated the inflammatory sites of Langerhans islets in the pancreas and also has a property capable of being activated upon absorption of a light ray or an X-ray of a specific wavelength, then irradiating the pancreas with the light ray or X-ray of the specific wavelength, and detecting or judging whether the fluorescence of the photo-excited photosensitizer or the X-ray absorption image occurs in the inflammatory sites of Langerhans islets or not.

Abstract: An endoscope apparatus has a side view endoscope 10 for side viewing an object in a radial direction of a distal end constitutional portion 14 and a balloon catheter 40. With an insert portion 13 of a side view endoscope 10 inserted in an insert tube 41 of the balloon catheter 40, the balloon catheter 40 is inserted into a blood vessel B. The insert tube 41 is provided at its distal end with a transparent balloon 42. This balloon 42 encloses the distal end constitutional portion 14. By feeding air (fluid) to this balloon 42, the balloon 42 is expanded so as to be urged against an inside wall of the blood vessel B. This causes the blood to be discharged between the inside wall of the blood vessel B and the balloon 42, thus enabling to observe the inside wall of the blood vessel B through the side view endoscope 10.

Abstract: In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

Abstract: An apparatus for measuring a glucose concentration is noninvasive, accurate, and compact. The apparatus includes a detection unit (10) and a principal component analysis (PCA) unit (20). The detection unit includes a light source (11) to emit mid-infrared light, an ATR prism (12) to receive the mid-infrared light with a measuring object placed on the ATR prism, and a spectrum detector (13) to detect an absorption spectrum from the mid-infrared light from the ATR prism. The PCA unit includes a loading memory (24) to store a glucose corresponding loading and a personal data memory (28) to store personal data in the form of a calibration curve. According to the detected absorption spectrum, stored loading, and stored personal data, the PCA unit computes a glucose concentration of the measuring object.

Abstract: Provided is an immunosuppressant composition for use in photochemotherapy which contains a tetrapyrrole derivative of general formula (I) undermentioned or a pharmacologically acceptable salt thereof.

Abstract: A hollow optical fiber 10 has an intermediate dielectric layer 12 interposed between an inner periphery side dielectric layer 11 facing a hollow core portion 10a and a metal layer 13. The inner periphery side dielectric layer 11 is formed of calcium fluoride. The intermediate dielectric layer 12 is formed of yttrium fluoride. Metal of the metal layer 13 can be prevented from dispersing into the dielectric layers 12, 11 by the intermediate dielectric layer 12 formed of yttrium fluoride. The hollow optical fiber 10 is manufactured by vapor depositing calcium fluoride on an outer peripheral surface of an acid-soluble glass tube 20 (base material), then vapor depositing yttrium fluoride on its outer peripheral surface, then vapor depositing a metal layer formed of silver, gold or the like on its outer peripheral surface, and thereafter, dissolving the glass tube 20 with acid.

Abstract: As a novel photochemotherapeutical method for the treatment or prevention of an auto-immune disease, there is provided a method for treating an auto-immune disease, which comprises administering to the patient mono-L-aspartyl chlorin e6 or mono-L-glutamyl chlorin e6 or a pharmacologically acceptable salt thereof, followed by subjecting the blood vessel blood of the patient containing the administered compound to exposure with an ultraviolet ray or a laser light, thereby to excite said compound photochemically. This method is effective to decrease the level of auto-antibody in the blood of the patient and is also of high safety.

Abstract: An X-ray-intercepting gold complex of mono-L-aspartyl (or mono-L-glutamyl) chlorin e6 or a salt thereof is used in the therapy of the tumor, cancer or arteriosclerosis lesions by X-ray irradiation. The complex provides a sharp x-ray image of tumor, solid cancer or lesions of arteriosclerosis. A similar platinum complex may also be utilized.

Abstract: An analysis system comprises an endoscope 10 (guiding apparatus) and a Raman analysis apparatus 40. An insert portion 12 of the endoscope 10 is inserted into the vessel. The endoscope 10 has a channel 10a formed therein and extending from an introducing pipe 18 of a grip 11 (main body portion) to a window formed in a distal end of the insert portion 12. An insert cable 54 of the Raman analysis apparatus 40 is inserted into the channel 10a. A single number of excitation optical fiber 60 and a bundle 70A of a plural number of light receiving optical fibers 70 are received in the insert cable 54. A basal end of the excitation optical fiber 60 is connected to an excitation light source 42, and a basal end of the light receiving optical fibers bundle 70A is connected to a spectroscope 41. An excitation light from the light source 42 is emitted from the window via the excitation optical fiber 60 and Raman scattered by impinging on matter adhered to an inside wall of the vessel.

Abstract: In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.