Abstract: 4-Anilinoquinazoline derivatives of formula (I): ##STR1## (in which: R.sup.1 represents a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group;R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, an alkoxy group or a halogen atom; andR.sup.3 represents a hydrogen atom cr a C.sub.1 -C.sub.4 alkyl group)and pharmaceutically acceptable salts thereof are, except where R.sup.1 represents a hydrogen atom or a chlorine atom in the 6- position when R.sup.2 and R.sup.3 both represent hydrogen atoms, new compounds and have been found to possess valuable analgesic and anti-inflammatory activities. These compounds can be prepared by heating the appropriate 4-haloquinazoline with an appropriate aniline or aniline derivative.

Abstract: A method of using 4-anilinoquinazoline derivatives of formula (I): ##STR1## (in which: R.sup.1 represents a hydrogen atom, a halogen, atom, a trifluoromethyl group or a nitro group;R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, an alkoxy group or a halogen atom; andR.sup.3 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group)and pharmaceutically acceptable salts thereof are, provided that R.sup.1 does not represents a hydrogen atom or a chlorine atom in the 6- position when R.sup.2 and R.sup.3 both represent hydrogen atoms, as an analgesic and anti-inflammatory in the treatment of mammals. These compounds can be prepared by heating the appropriate 4-haloquinazoline with an appropriate aniline or aniline derivative.

Abstract: 3-[2-(4-PHENYL-1-PIPERAZINYL)ETHYL]-4H-pyrido[1,2-a]pyrimidin-4-one derivatives have central nervous depressant and hypotensive activities and are useful as major tranquillizers.The compounds can be prepared by (a) reacting 2-methyl-3-halogeno (or arylsulfonyloxy or alkylsulfonyloxy)ethyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative with 1-phenylpiperazine derivative or (b) reacting an aminopyridine with 2-[2-(4-phenyl-1-piperazinyl)ethyl]-acetoacetic acid ester.