Abstract: Provided is a composition for promotion of the regeneration of the nucleus pulposus of an intervertebral disc, said composition comprising a low endotoxin monovalent metal salt of alginic acid and mesenchymal stem cells. In particular, the composition of the present invention promotes the regeneration of the nucleus pulposus of an intervertebral disc via activation of nucleus pulposus cells by human bone marrow-derived high-purity mesenchymal stem cells and/or differentiation of human bone marrow-derived high-purity mesenchymal stem cells into nucleus pulposus cells.

Abstract: Provided is a composition for suppressing pain which contains a monovalent metal salt of alginic acid, the composition being applied to a nucleus pulposus cavity part to suppress pain at a surgical site and/or a surrounding site thereof which occurs after surgery. Accordingly, a composition is provided, which suppresses pain and/or inflammation at a surgical site and/or a surrounding site thereof which occurs after surgery performed on an intervertebral disc as typified by intervertebral discectomy.