Patents by Inventor Katsushige Yamada

Katsushige Yamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240294583
    Abstract: A genetically modified microorganism containing a gene capable of expressing a mutated YeeX protein or a homolog thereof, which results from substitution, insertion, and/or deletion of one to several amino acids in the amino acid sequence of the wild-type YeeX protein or of a homolog thereof, has a higher capacity to produce an organic acid(s) than the genetically unmodified original microorganism.
    Type: Application
    Filed: May 11, 2021
    Publication date: September 5, 2024
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Hitomi NAKAMURA, Kyohei ISOBE, Kenji KAWAMURA, Katsushige YAMADA
  • Patent number: 12037624
    Abstract: A mutant of a trichoderma filamentous fungus has a mutation that results in lost or lowered function of a beta-adaptin large subunit, or a mutation in an amino acid sequence that forms the beta-adaptin large subunit. A method produces a protein while maintaining a low viscosity in a culture solution during culturing by using the mutant.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: July 16, 2024
    Assignee: Toray Industries, Inc.
    Inventors: Yusuke Kagawa, Shingo Hiramatsu, Katsushige Yamada
  • Publication number: 20240140927
    Abstract: A 3-hydroxyadipic acid-3,6-lactone composition includes 3-hydroxyadipic acid-3,6-lactone, and 3 to 30 parts by weight of ?-hydromuconic acid with respect to 100 parts by weight of the 3-hydroxyadipic acid-3,6-lactone; and a method produces a 3-hydroxyadipic acid-3,6-lactone composition, the method including a step of heating 3-hydroxyadipic acid-3,6-lactone to obtain the 3-hydroxyadipic acid-3,6-lactone composition.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 2, 2024
    Inventors: Daijiro Tsukamoto, Kenji Kawamura, Katsushige Yamada
  • Publication number: 20230392112
    Abstract: Disclosed are a genetically modified microorganism that can produce 3-hydroxyadipic acid and/or ?-hydromuconic acid in high yields, and the genetically modified microorganism. The genetically modified microorganism is a microorganism having an ability to produce 3-hydroxyadipic acid and/or ?-hydromuconic acid, in which the reaction to generate acetyl-CoA from pyruvic acid is enhanced and function of pyruvate kinase and/or phosphotransferase system is reduced.
    Type: Application
    Filed: November 10, 2021
    Publication date: December 7, 2023
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Kyohei ISOBE, Kenji KAWAMURA, Katsushige YAMADA
  • Patent number: 11760739
    Abstract: A method relates to producing 3-hydroxyadipic acid-3,6-lactone, the method including the following steps (A) and (B): (A) a step of adding an acid to a 3-hydroxyadipic acid-containing aqueous solution to obtain a 3-hydroxyadipic acid-3,6-lactone-containing aqueous solution; and (B) a step of obtaining a 3-hydroxyadipic acid-3,6-lactone extract by bringing the 3-hydroxyadipic acid-3,6-lactone-containing aqueous solution obtained in step (A) into contact with an extraction solvent that is phase-separated from the solution.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: September 19, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Daijiro Tsukamoto, Kenji Kawamura, Katsushige Yamada
  • Patent number: 11753662
    Abstract: A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: September 12, 2023
    Assignee: TORAY INDUSTRIES, INC.
    Inventors: Kyohei Isobe, Kenji Kawamura, Masateru Ito, Katsushige Yamada
  • Patent number: 11732284
    Abstract: A mutant strain of Trichoderma reesei has a mutation that eliminates or reduces a function of a polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 2. A method produces a protein, the method including a step of cultivating the mutant strain.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: August 22, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Yusuke Kagawa, Shingo Hiramatsu, Katsushige Yamada
  • Publication number: 20230101086
    Abstract: A genetically modified microorganism that can produce 3-hydroxyadipic acid and/or ?-hydromuconic acid with a high yield; and a method of producing 3-hydroxyadipic acid and/or ?-hydromuconic acid using the genetically modified microorganism, are disclosed. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid and/or ?-hydromuconic acid, and has an enhanced enzymatic activity to catalyze a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, wherein, in the genetically modified microorganism, a dicarboxylic acid excretion carrier function is deleted or decreased.
    Type: Application
    Filed: March 17, 2021
    Publication date: March 30, 2023
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Kyohei ISOBE, Kenji KAWAMURA, Katsushige YAMADA
  • Patent number: 11608493
    Abstract: A mutant strain of a filamentous fungus of the genus Trichoderma having a reduced function of a polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 2; and a method of producing a sugar from a cellulose-containing biomass, the method including: step a of producing a cellulase by cultivating a Trichoderma reesei mutant strain having a reduced function of a polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 2, and step b of saccharifying the biomass by using the cellulase obtained in the step a.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: March 21, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Yusuke Kagawa, Shingo Hiramatsu, Katsushige Yamada
  • Patent number: 11597694
    Abstract: Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 ?m and less than 1 ?m with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: March 7, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Kenji Sawai, Hideki Sawai, Takashi Mimitsuka, Masateru Ito, Katsushige Yamada, Kenji Kawamura, Shin-ichi Minegishi, Izumi Nakagawa, Tatsuya Nagano
  • Publication number: 20220411379
    Abstract: The present invention relates to a method of producing ?-caprolactam, the method including the following steps (A) and (B): (A) a step of reacting 5-cyanovaleramide with hydrogen in an aqueous solvent in a presence of a hydrogenation catalyst to obtain a 5-cyanovaleramide hydrogenation reaction mixture; (B) a step of heating the 5-cyanovaleramide hydrogenation reaction mixture at a temperature of 180° C. or higher and 300° C. or lower in an aqueous solvent to obtain ?-caprolactam.
    Type: Application
    Filed: November 18, 2020
    Publication date: December 29, 2022
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Daijiro TSUKAMOTO, Kenji KAWAMURA, Katsushige YAMADA, Masato AKAHIRA, Daisuke YAMAMOTO
  • Publication number: 20220356140
    Abstract: The present invention relates to a method of producing adipic acid, including a step (hydrogenation step) of reacting 3-hydroxyadipic acid-3,6-lactone with hydrogen in an aqueous solvent in a presence of a hydrogenation catalyst. The hydrogenation catalyst preferably includes one kind or two or more kinds of transition metal elements selected from the group consisting of palladium, platinum, ruthenium, rhodium, rhenium, nickel, cobalt, iron, iridium, osmium, copper, and chromium.
    Type: Application
    Filed: September 24, 2020
    Publication date: November 10, 2022
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Daijiro TSUKAMOTO, Kenji KAWAMURA, Katsushige YAMADA, Masato AKAHIRA, Daisuke YAMAMOTO
  • Patent number: 11492603
    Abstract: A Trichoderma reesei mutant strain has a function of a polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 2 is reduced. A method of producing a protein includes a step of cultivating the Tricho-derma reesei mutant strain, and a method of producing a cellulase includes a step of cultivating the Trichoderma reesei mutant strain.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: November 8, 2022
    Assignee: Toray Industries, Inc.
    Inventors: Yusuke Kagawa, Haruka Saito, Shingo Hiramatsu, Katsushige Yamada
  • Patent number: 11453899
    Abstract: A method produces a protein using a filamentous fungus, in which decrease in dissolved oxygen saturation during culture of the filamentous fungus can be suppressed even when the culture is scaled up. The method of producing a protein includes culturing a fungus belonging to the genus Trichoderma whose BXL1 gene was disrupted, using a biomass containing cellulose and xylan as an inducer. The use of the BXL1 gene-disrupted fungus belonging to the genus Trichoderma enables suppression of the decrease in dissolved oxygen saturation even when xylose and cellulose are used as inducers.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 27, 2022
    Assignee: Toray Industries, Inc.
    Inventors: Koji Kobayashi, Shingo Hiramatsu, Katsushige Yamada
  • Patent number: 11413582
    Abstract: A filtration device includes a continuous first unit including a first membrane that separates a liquid into first permeated and non-permeated liquids, a first adjuster that adjusts a flow rate of the first permeated liquid to be substantially constant, and a first liquid scale that detects a liquid amount, a second unit including a second membrane that separates another liquid into second permeated and non-permeated liquids, a second adjuster that adjusts a flow rate of the second permeated liquid to be substantially constant, and a second liquid scale that detects another liquid amount, a first controller that controls the liquid amount in the first storage tank based on measurement values from continuous two first units or from the continuous first and second units, and a second controller that controls the another liquid amount based on a measurement value from the second unit.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: August 16, 2022
    Assignee: Toray Industries, Inc.
    Inventors: Yuka Asahi, Atsushi Minamino, Hiroyuki Kurihara, Katsushige Yamada
  • Publication number: 20220228178
    Abstract: Disclosed are a genetically modified microorganism with an ability to produce 3-hydroxyadipic acid, ?-hydromuconic acid, and/or adipic acid in high yield, and a method of producing 3-hydroxyadipic acid, ?-hydromuconic acid, and/or adipic acid by using the genetically modified microorganism. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid, ?-hydromuconic acid, and/or adipic acid and is deficient in the function of pyruvate kinase, in which the activities of phosphoenolpyruvate carboxykinase and of an enzyme that catalyzes the reaction of reducing 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA are enhanced.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 21, 2022
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Kyohei ISOBE, Kenji KAWAMURA, Katsushige YAMADA
  • Publication number: 20220213514
    Abstract: Disclosed is a genetically modified microorganism that produces 3-hydroxyadipic acid, ?-hydromuconic acid. or adipic acid in high yield. A nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or the expression of the polypeptide is enhanced and the function of pyruvate kinase is impaired in the genetically modified microorganism: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 7; (b) a polypeptide having the same amino acid sequence as any one of those amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, andor added, and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA; (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of those amino acid sequences and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 7, 2022
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Kyohei ISOBE, Kenji KAWAMURA, Katsushige YAMADA
  • Publication number: 20220185786
    Abstract: A method relates to producing 3-hydroxyadipic acid-3,6-lactone, the method including the following steps (A) and (B): (A) a step of adding an acid to a 3-hydroxyadipic acid-containing aqueous solution to obtain a 3-hydroxyadipic acid-3,6-lactone-containing aqueous solution; and (B) a step of obtaining a 3-hydroxyadipic acid-3,6-lactone extract by bringing the 3-hydroxyadipic acid-3,6-lactone-containing aqueous solution obtained in step (A) into contact with an extraction solvent that is phase-separated from the solution.
    Type: Application
    Filed: March 24, 2020
    Publication date: June 16, 2022
    Inventors: Daijiro Tsukamoto, Kenji Kawamura, Katsushige Yamada
  • Publication number: 20220162148
    Abstract: A method of producing an ?,?-unsaturated dicarboxylic acid ester exemplified by an ?-hydromuconic acid ester from a carboxylic acid ester exemplified by a 3-hydroxyadipic acid ester or a 3-hydroxyadipic acid-3,6-lactone ester, in which the selectivity for the ?,?-unsaturated dicarboxylic acid ester can be increased by subjecting the carboxylic acid ester to a basic condition of pH 8.5 to less than 13 in an organic solvent or a mixed solvent of an organic solvent and water.
    Type: Application
    Filed: February 25, 2020
    Publication date: May 26, 2022
    Inventors: Hitomi Nakamura, Daijiro Tsukamoto, Kenji Kawamura, Katsushige Yamada
  • Publication number: 20220090148
    Abstract: Efficient production of a carboxylic acid is provided by a method of producing a carboxylic acid, which includes the following steps (A) and (B): (A) filtering a carboxylic acid-containing fermentation broth by passing said fermentation broth through a nanofiltration membrane, to obtain a carboxylic acid-containing filtrate from the permeate side of the membrane; and (B) extracting the carboxylic acid from the carboxylic acid-containing filtrate obtained in the step (A) using an extraction solvent which undergoes phase separation with the filtrate, and collecting a carboxylic acid extract phase-separated from the aqueous phase.
    Type: Application
    Filed: March 24, 2020
    Publication date: March 24, 2022
    Inventors: Daijiro Tsukamoto, Jenji Kawamura, Katsushige Yamada