Patents by Inventor Katsutoshi Kokubun

Katsutoshi Kokubun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9815866
    Abstract: [Problem to be Solved] An object of the present invention is to provide a novel peptide that has the high ability to bind to EpCAM, which can be easily prepared by a chemical synthesis method or a genetic engineering method. [Solution] The present inventors have improved a method for screening a phage library and thereby successfully screened for a peptide that has the higher ability to bind to EpCAM compared with publicly known peptides. The present inventors have also used an already disclosed peptide having the ability to bind to EpCAM as a lead compound to prepare diverse populations of derivatives thereof, from among which a peptide strongly binding to EpCAM has been selected. The obtained peptides exhibit at least 10 times higher ability to bind to EpCAM compared with publicly known peptides and as such, are effective for the detection or diagnosis of cancer cells.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: November 14, 2017
    Assignee: JAPANESE FOUNDATION FOR CANCER RESEARCH
    Inventors: Kiyotaka Shiba, Katsutoshi Kokubun, Kanako Suga
  • Patent number: 9808174
    Abstract: Upon detecting a body-motion before starting a main-imaging, a sequence-switching control-unit controls operation so as to switch from a usual-imaging sequence to a body-motion adaptive-sequence corresponding to an imaging-portion of a subject P by referring to a body-motion adaptive-sequence storage-unit. Moreover, upon detecting a body-motion during the main-imaging according to the usual-imaging sequence, the sequence-switching control-unit refers to a collected-data storage-unit, and controls operation so as to perform a retake by switching to the body-motion adaptive-sequence if an already-collected data-volume is less than a predetermined volume. By contrast, if the already-collected data-volume is equal to or more than the predetermined volume at a time of detecting a body-motion during the main-imaging, the sequence-switching control-unit stops the main-imaging, and controls a data-processing unit so as to reconstruct a magnetic resonance image only with collected data.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: November 7, 2017
    Assignee: Toshiba Medical Systems Corporation
    Inventor: Katsutoshi Kokubun
  • Publication number: 20150246945
    Abstract: [Problem to be Solved] An object of the present invention is to provide a novel peptide that has the high ability to bind to EpCAM, which can be easily prepared by a chemical synthesis method or a genetic engineering method. [Solution] The present inventors have improved a method for screening a phage library and thereby successfully screened for a peptide that has the higher ability to bind to EpCAM compared with publicly known peptides. The present inventors have also used an already disclosed peptide having the ability to bind to EpCAM as a lead compound to prepare diverse populations of derivatives thereof, from among which a peptide strongly binding to EpCAM has been selected. The obtained peptides exhibit at least 10 times higher ability to bind to EpCAM compared with publicly known peptides and as such, are effective for the detection or diagnosis of cancer cells.
    Type: Application
    Filed: September 12, 2013
    Publication date: September 3, 2015
    Inventors: Kiyotaka Shiba, Katsutoshi Kokubun, Kanako Suga
  • Publication number: 20100152568
    Abstract: When determined that a body-motion is produced before starting a main-imaging, a sequence-switching control-unit controls operation so as to switch from a usual-imaging sequence to a body-motion adaptive-sequence corresponding to an imaging-portion of a subject P by referring to a body-motion adaptive-sequence storage-unit. Moreover, upon a determination that a body-motion is produced during the main-imaging according to the usual-imaging sequence, the sequence-switching control-unit refers to a collected-data storage-unit, and controls operation so as to perform a retake by switching to the body-motion adaptive-sequence if an already-collected data-volume is less than a predetermined volume.
    Type: Application
    Filed: December 2, 2009
    Publication date: June 17, 2010
    Applicants: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MEDICAL SYSYTEMS CORPORATION
    Inventor: Katsutoshi KOKUBUN
  • Patent number: 7642778
    Abstract: An MRI apparatus for performing an MRI examination to an object by sequentially applying an imaging method group, which is constituted by time-sequentially arranging a plurality of different imaging methods, to each of the imaging methods, has an imaging method group setting unit, a performing order setting unit and an imaging condition setting unit. The imaging method group setting unit sets the imaging method group. The performing order setting unit sets a performing order as a performing order of the imaging methods constituting the imaging method group. The imaging condition setting unit sets an imaging condition to each of the imaging methods.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: January 5, 2010
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventors: Kazuya Tanoue, Katsutoshi Kokubun, Yoshiteru Watanabe
  • Publication number: 20080211496
    Abstract: An MRI apparatus for performing an MRI examination to an object by sequentially applying an imaging method group, which is constituted by time-sequentially arranging a plurality of different imaging methods, to each of the imaging methods, has an imaging method group setting unit, a performing order setting unit and an imaging condition setting unit. The imaging method group setting unit sets the imaging method group. The performing order setting unit sets a performing order as a performing order of the imaging methods constituting the imaging method group. The imaging condition setting unit sets an imaging condition to each of the imaging methods.
    Type: Application
    Filed: January 15, 2008
    Publication date: September 4, 2008
    Applicants: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Kazuya Tanoue, Katsutoshi Kokubun, Yoshiteru Watanabe
  • Patent number: 5898305
    Abstract: A magnetic resonance imaging apparatus comprises a collecting section that collects from the subject the magnetic resonance signals corresponding to N phase encode data items for restructuring each of a plurality of images, a restructuring section that restructures each set of N phase encode data items corresponding to the magnetic resonance signals obtained by the collecting section, an image processing section that processes the restructured images obtained at the restructuring section, an image output section that outputs the processed images obtained at the image processing section, and a changing section that changes the number of phase encode data items updated among the N phase encode data items restructured at the restructuring section, while the collecting section is in operation.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: April 27, 1999
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Katsutoshi Kokubun, Takeshiro Suzuki, Masaaki Yui