Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.

Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.

Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.

Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to the peptide substrate by using an anti-acetylated peptide antibody. This system for detecting acetyltransferase and deacetylase activities using the anti-acetylated peptide antibody enables screening inhibitors or enhancers of acetyltransferase and deacetylase. A system for screening deacetylase inhibitors or acetyltransferase enhancers using cultured cells is also provided.

Abstract: The present invention provides methods for measuring the phosphorylation activity of Cdc7-ASK kinase complex by using as an indicator the level of phosphorylation at a phosphorylation site of MCM, which is a substrate of Cdc7-ASK kinase complex. The effects of test compounds on the phosphorylation activity of Cdc7-ASK kinase complex can also be evaluated based on these measurement methods. Compounds that inhibit this phosphorylation activity are useful as anti-cancer agents having superior specificity for cancer.

Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to the peptide substrate by using an anti-acetylated peptide antibody. This system for detecting acetyltransferase and deacetylase activities using the anti-acetylated peptide antibody enables screening inhibitors or enhancers of acetyltransferase and deacetylase. A system for screening deacetylase inhibitors or acetyltransferase enhancers using cultured cells is also provided.

Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.

Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Abstract: An external expansion bus interface circuit is provided for connecting a peripheral to a micro control unit to exchange digital information under an external expansion memory mode of the micro control unit. For this purpose, the eternal expansion bus interface circuit includes a means for storing a writing data. Address decoder and a strobe decoder are connected to the micro control unit to directly receive the writing data, an address strobe, and a write strobe. Then the address decoder and strobe decoder produce a write enable signal for enabling the memory to store the data at address designated thereby.

Abstract: A three-way electromagnetic valve provided with a valve body, a movable member slidably disposed in the valve body, an actuator for driving the movable member, an opening-closing mechanism provided in an internal passage formed in the movable member. A clearance reducing portion is formed to reduce a gap created by a pressurized fluid entering the slide section or by the force of fastening and fixing the valve body, thereby limiting the leakage of the pressurized fluid.

Abstract: Intake and exhaust ports of an internal combustion engine possess respective turbine impellers, and an electrical rotary machine is formed on a rotary shaft connecting the impellers. Sensors are provided for sensing the loaded state of the engine at all times based on engine rpm and the amount of fuel supplied to the engine. When the engine is overloaded, the electrical rotary machine is made to operate as a motor to assist in the supercharging of the engine. When the engine load is not excessive, the rotary machine is made to operate as a generator to charge surplus energy, derived from the engine exhaust, in a storage battery.

Abstract: An electric generator for use in a turbocharger includes a rotor mounted on the rotational shaft of the turbocharger and comprising a single permanent magnet fitted in an outer cylindrical sleeve which prevents the rotor from breakage upon high-speed rotaiton thereof. The rotor also includes heat insulation between the permanent magnet and the rotational shaft. The heat insulation portion may be an air gap or a heat insulating member.

Abstract: An energy recovery apparatus for a turbo compound engine is provided having an exhaust turbine with a first rotary machine in an exhaust pipe of an internal combustion engine; a second rotary machine mounted on a wheel axle of a motor vehicle which is driven by the internal combustion engine, and an exhaust turbine coupled to the exhaust port of the first-mentioned exhaust turbine; and a third rotary machine operable as a generator. The energy recovery apparatus also includes a first sensor for detecting the speed of rotation of the internal combustion engine and a second sensor for detecting the load on the engine. The first through third rotary machines are controlled by signals from the sensors and efficiently utilize the exhaust energy carried by the exhaust gas discharged from the internal combustion engine.

Abstract: A motor/generator is mounted on the turbine shaft of a supercharger in an internal combustion engine. Whether the motor/generator should operate as a motor or a generator is determined by a signal from a flow rate sensor that detect the rate of fuel flow and a signal from a rotation sensor that detects rotation of the internal combustion engine. When the motor/generator operates as a generator, the fuel flow rate is controlled in response to an output signal indicative of electric power from the generator. When the motor/generator operates as a motor, electric power supplied thereto is controlled in response to an accumulated value of supplied electric power.