Patents by Inventor Katy REZVANI

Katy REZVANI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treatment with natural killer cells matched for killer immunoglobulin receptor type
    Patent number: 11154572
    Abstract: The present invention concerns methods of treating a disease such as leukemia in a subject by administering natural killer (NK) cells. In particular aspects, HLA-C1-licensed KIR2DL2/3 and KIR2DS2 NK cells are administered to a subject with an HLA-C genotype either homozygous or heterozygous for the C1 allele, or HLA-C2 licensed cells are administered to a subject with an HLA-C genotype homozygous for the C2 allele. In further aspects, the NK cells are genetically modified to express a chimeric antigen receptor and interleukin 15.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: October 26, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Katy Rezvani, Elizabeth Shpall, Enli Liu
  • ENHANCED CHIMERIC ANTIGEN RECEPTORS AND USE THEREOF
    Publication number: 20210253729
    Abstract: Provided herein are chimeric antigen receptors (CARs) comprising a truncated EGFRvIII (Ev3) in the hinge region of the CAR and/or a humanized scFv. Further provided herein are immune cells expressing the CARs as well as methods of their use in the treatment of immune disorders.
    Type: Application
    Filed: April 16, 2021
    Publication date: August 19, 2021
    Inventors: Sonny Oon Ang, Enli Liu, Elizabeth Shpall, Katy Rezvani
  • NATURAL KILLER CELLS ENGINEERED TO EXPRESS CHIMERIC ANTIGEN RECEPTORS WITH IMMUNE CHECKPOINT BLOCKADE
    Publication number: 20210230548
    Abstract: Provided herein are methods for producing NK cells expressing chimeric antigen receptors and having no expression of CISH. Further provided are methods for treating diseases by administering the CAR NK cells.
    Type: Application
    Filed: May 3, 2019
    Publication date: July 29, 2021
    Inventors: May Daher, Rafet Basar, Elizabeth Shpall, Katy Rezvani
  • METHODS FOR PRODUCTION OF MSC-DERIVED EXOSOMES
    Publication number: 20210186877
    Abstract: Provided herein are methods of manufacturing clinical grade exosomes derived from mesenchymal stem cells (MSCs). Further provided are methods of loading the exosomes with therapeutic agents, such as siRNA. Also provided herein are methods of treating diseases by administering the clinical grade exosomes.
    Type: Application
    Filed: November 16, 2018
    Publication date: June 24, 2021
    Inventors: Elizabeth Shpall, Raghu Kalluri, Katy Rezvani, Mayela Mendt, Valerie Lebleu, Sushrut Kamerkar
  • METHODS FOR PRODUCING REGULATORY IMMUNE CELLS AND USES THEREOF
    Publication number: 20210147800
    Abstract: Provided herein are methods for expanding populations of regulatory B cells comprising treating a population of B cells with IL-4 and CD40 ligand. Further provided herein are methods of expanding populations of regulatory T cells comprising expanding a population of T cells under Treg expansion conditions and selecting for CD9+ Tregs. Also provided herein are methods of treating immune disorders with the regulatory B cells and/or regulatory T cells.
    Type: Application
    Filed: June 22, 2018
    Publication date: May 20, 2021
    Inventors: Katy Rezvani, Elizabeth Shpall, Rafet Basar
  • UNIVERSAL ANTIGEN PRESENTING CELLS AND USES THEREOF
    Publication number: 20200390815
    Abstract: Provided herein are universal antigen presenting cells. Also provided herein are methods of expanding immune cells using the UAPCs and methods for the treatment of a disease, such as cancer, using the expanded immune cells.
    Type: Application
    Filed: February 21, 2019
    Publication date: December 17, 2020
    Inventors: Sonny O. T. Ang, Enli Liu, Elizabeth Shpall, Katy Rezvani
  • METHODS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND USES THEREOF
    Publication number: 20200390816
    Abstract: Provided herein are methods for pre-activating and expanding an isolated population of NK cells. Further provided herein are methods for the treatment of cancer by administering the pre-activated and expanded NK cells.
    Type: Application
    Filed: February 21, 2019
    Publication date: December 17, 2020
    Inventors: Lucilla Nassif Kerbauy, Elizabeth Shpall, Katy Rezvani
  • BK virus specific T cells
    Patent number: 10821134
    Abstract: Provided herein are methods of rapidly expanding BKV-specific T cells using a peptide mixture and cytokines. Further provided herein are methods of treating polyomavirus-associated diseases by administering the BKV-specific T cells.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: November 3, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Katy Rezvani, Elizabeth Shpall, Muharrem Muftuoglu
  • REGULATORY B CELLS AND USES THEREOF
    Publication number: 20200113939
    Abstract: Provided herein are methods for producing stimulated populations of regulatory B cells comprising treating an isolated population of B cells with stimulatory agents, such as CpG oligonucleotides, BCR ligation, and CD40 ligand. Also provided herein are methods of treating immune disorders, such as chronic graft versus host disease, with the stimulated population of regulatory B cells.
    Type: Application
    Filed: July 14, 2017
    Publication date: April 16, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Katy REZVANI, Elizabeth SHPALL, Nobuhiko IMAHASHI
  • IMMUNE CELLS EXPRESSING ENGINEERED ANTIGEN RECEPTORS
    Publication number: 20200085872
    Abstract: Provided herein are immune cells expressing antigenic receptors, such as a chimeric antigen receptor and a T cell receptor. Further provided herein are methods of treating immune-related disorder by administering the antigen-specific immune cells.
    Type: Application
    Filed: April 19, 2018
    Publication date: March 19, 2020
    Inventors: Katy REZVANI, Elizabeth J. SHPALL
  • METHODS OF TREATMENT WITH NATURAL KILLER CELLS MATCHED FOR KILLER IMMUNOGLOBULIN RECEPTOR TYPE
    Publication number: 20180353544
    Abstract: The present invention concerns methods of treating a disease such as leukemia in a subject by administering natural killer (NK) cells. In particular aspects, HLA-C1-licensed KIR2DL2/3 and KIR2DS2 NK cells are administered to a subject with an HLA-C genotype either homozygous or heterozygous for the C1 allele, or HLA-C2 licensed cells are administered to a subject with an HLA-C genotype homozygous for the C2 allele. In further aspects, the NK cells are genetically modified to express a chimeric antigen receptor and interleukin 15.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 13, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Katy REZVANI, Elizabeth SHPALL, Enli LIU
  • BK VIRUS SPECIFIC T CELLS
    Publication number: 20180333435
    Abstract: Provided herein are methods of rapidly expanding BKV-specific T cells using a peptide mixture and cytokines. Further provided herein are methods of treating polyomavirus-associated diseases by administering the BKV-specific T cells.
    Type: Application
    Filed: May 17, 2018
    Publication date: November 22, 2018
    Inventors: Katy REZVANI, Elizabeth SHPALL, Muharrem MUFTUOGLU