Patents by Inventor Katya Pavlova Nacheva

Katya Pavlova Nacheva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-aminolevulinate synthase inhibitors and methods of use thereof
    Patent number: 11479532
    Abstract: Disclosed herein, are 5-Aminolevulinate synthase inhibitors and methods for their use in the treatment of porphyria.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: October 25, 2022
    Assignee: University of South Florida
    Inventors: Roman Manetsch, Gloria C. Ferreira, Bosko M. Stojanovski, Katya Pavlova Nacheva
  • 5-AMINOLEVULINATE SYNTHASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20210269397
    Abstract: Disclosed herein, are 5-Aminolevulinate synthase inhibitors and methods for their use in the treatment of porphyria. In at least one specific embodiment, the 5-Aminolevulinate synthase inhibitors can include compounds or salts thereof of Formulas (I-V).
    Type: Application
    Filed: June 21, 2018
    Publication date: September 2, 2021
    Applicant: University of South Florida
    Inventors: Roman MANETSCH, Gloria C. FERREIRA, Bosko M. STOJANOVSKI, Katya Pavlova NACHEVA
  • Target binding molecules identified by kinetic target-guided synthesis
    Patent number: 10551389
    Abstract: Methods of identifying target binding molecules by target guided synthesis are provided. The methods include providing two or more fragments capable of reacting to form the target binding molecule and mixing the fragments with the target. The methods can be used to identify target binding molecules that bind targets such as proteins or nucleic acids, including those that bind shallow binding pockets on the surface of such targets. The methods are applied to the Bcl-XL and Mcl-1 proteins from the Bcl-2 family of proteins. Using thio acid and sulfonyl azide fragments capable of reacting through sulfo-click chemistry, new acyl sulfonamides are identified that bind one or both of the Bcl-XL and Mcl-1 proteins. Pharmaceutical formulations of these target binding molecules are also provided.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 4, 2020
    Assignees: University of South Florida, The Penn State Research Foundation
    Inventors: Roman Manetsch, Katya Pavlova Nacheva, David Lawrence Flanigan, Niranjan Kumar Namelikonda, Iredia David Iyamu, Sameer Shamrao Kulkarni, Megan M. Barber, Jeremiah Dwayne Tipton, Hong-Gang Wang, Kenichiro Doi
  • Target Binding Molecules Identified by Kinetic Target-Guided Synthesis
    Publication number: 20160116482
    Abstract: Methods of identifying target binding molecules by target guided synthesis are provided. The methods include providing two or more fragments capable of reacting to form the target binding molecule and mixing the fragments with the target. The methods can be used to identify target binding molecules that bind targets such as proteins or nucleic acids, including those that bind shallow binding pockets on the surface of such targets. The methods are applied to the Bcl-XL and Mcl-1 proteins from the Bcl-2 family of proteins. Using thio acid and sulfonyl azide fragments capable of reacting through sulfo-click chemistry, new acyl sulfonamides are identified that bind one or both of the Bcl-XL and Mcl-1 proteins. Pharmaceutical formulations of these target binding molecules are also provided.
    Type: Application
    Filed: August 6, 2014
    Publication date: April 28, 2016
    Applicants: THE PENN STATE RESEARCH FOUNDATION, University of South Flordia
    Inventors: Roman Manetsch, Katya Pavlova Nacheva, David Lawrence Flanigan, Niranjan Kumar Namelikonda, Iredia David Iyamu, Sameer Shamrao Kulkarni, Megan M. Barber, Jeremiah Dwayne Tipton, Hong-Gang Wang, Kenichiro Doi