Abstract: An apparatus and a system for filtering a liquid sample in a sample well (310) by transferring the liquid out of the sample well (310) through a filter member (320) situated at a bottom part of the sample well (310). The apparatus and the system include a syringe (100), and a seal member (200) arranged around a nozzle (140) of the syringe (100) in such a way that the syringe (100) is adjustable in connection with an upper part of the sample well (310) in a substantially airtight manner. A method for filtering a liquid sample and use of the system for filtering eluted blood are also disclosed.

Abstract: An apparatus and a system for filtering a liquid sample in a sample well (310) by transferring the liquid out of the sample well (310) through a filter member (320) situated at a bottom part of the sample well (310). The apparatus and the system include a syringe (100), and a seal member (200) arranged around a nozzle (140) of the syringe (100) in such a way that the syringe (100) is adjustable in connection with an upper part of the sample well (310) in a substantially airtight manner. A method for filtering a liquid sample and use of the system for filtering eluted blood are also disclosed.

Abstract: The invention relates to a punching tool for taking a biological sample from a filter using punching, the punching tool comprising a punch and a die provided with a punching channel for conveying the sample from the upper surface of the die towards the lower end of the die that includes a guidance means of the sample comprising a guidance channel arranged as an extension of the punching channel for receiving the sample from the punching channel, the diameter of the guidance channel is 1.02 to 2× the diameter of the punch and is greater than the diameter of the punching channel, and at the connecting point with the punching channel the guidance channel forms a shoulder and broadens towards the free end of the guidance means.

Abstract: The invention concerns an apparatus and a method for collecting data on a set of light-emitting molecular reactions. The apparatus comprises a holder for a reaction vessel comprising a plurality of reaction spaces containing first reaction substance, feeder for supplying second reaction substance to said reaction spaces for initiating said reaction set, and a plurality of light detectors for measuring light emitted from said reaction spaces in synchronized relationship with said feeding. According to the invention, at least two of said light detectors are arranged on opposing sides of the reaction vessel and being adapted to simultaneously measure different properties of the reaction set, that is, different wells or wavelengths, for example. The invention allows doubling the measurement speed in aequorin-based intracellular Ca-measurements.

Abstract: The invention relates to a punching tool for taking a biological sample from a filter using punching, the punching tool comprising a punch and a die provided with a punching channel for conveying the sample from the upper surface of the die towards the lower end of the die that includes a guidance means of the sample comprising a guidance channel arranged as an extension of the punching channel for receiving the sample from the punching channel, the diameter of the guidance channel is 1,02 to 2× the diameter of the punch and is greater than the diameter of the punching channel, and at the connecting point with the punching channel the guidance channel forms a shoulder and broadens towards the free end of the guidance means.

Abstract: A method and a multichannel pipetting apparatus (40) for simultaneous pipetting of a plurality of sample wells (44) or containers. The pipetting channels (12) of the apparatus have been divided into groups, which are connected via an adapter (30) containing a plurality of channels (31) to pipetting tips (20) of a known type. By changing the adapter or the adapter zone (22), a suitable configuration for different sample plates (42) or containers is selected.

Abstract: A sample handling method, in which the information on the sample to be examined is transferred throughout the entire measuring process by transferring the sample cup. The sample cups are handled in two independently operating drums, in which case at least two different handling phases can be carried out simultaneously in the measuring device. The diagnostic measuring device comprises a cassette drum, on the circumference of which the sample cup cassettes containing sample cups have been placed. The sample cup is fed to the first handling drum, which is simultaneously an incubation drum. After that the sample cup is transferred to a second handling drum, where washing, drying, measuring and discharge of the sample cup are carried out. The drums have been placed near each other, overlapping so that the transfers of the sample cup can be performed directly from one drum to another by means of transfer plungers.

Abstract: A method and a multichannel pipetting apparatus (40) for simultaneous pipetting of a plurality of sample wells (44) or containers. The pipetting channels (12) of the apparatus have been divided into groups, which are connected via an adapter (30) containing a plurality of channels (31) to pipetting tips (20) of a known type. By changing the adapter or the adapter zone (22), a suitable configuration for different sample plates (42) or containers is selected.

Abstract: A method for taking a sample from a closed test tube without removing the stopper of the test tube. According to the method, the stopper of the test tube is pierced with a disposable piercing needle through which the sample is taken to the sample receptacle of the sampling device. From there the sample is dispensed with a dispenser needle. The sampling device comprises an adapting element for fitting the test tube, with the piercing needle first, to the sampling device, a cup-like sample receptacle and a suction device for drawing the sample that is in the test tube into the sample receptacle.

Abstract: A device for counting liquid scintillation samples which can count a single sample or several samples simultaneously. A transport system moves samples from a storage section to a counting section. The samples are placed on sample plate holders to assist the transport system in movement of the sample from the storage section to the counting section.

Abstract: An invention for preventing optical crosstalk in a process of counting liquid scintillation samples deposited in a sample plate, the sample plate composed of a plurality of sample wells, the optical crosstalk being caused by mutual optical affection between samples deposited in the sample wells. Sample wells are provided with tubes made of material impermeable but reflective or scattering for scintillation light generated by the samples.

Abstract: An arrangement for counting liquid scintillation samples on bottom-window multi-well sample plates in a liquid scintillation counter. The sample plates include a plurality of samples wells having light impermeable side walls and a light permeable bottom sheet which covers and forms the bottoms of said sample wells. The liquid scintillation counter includes at least one photomultiplier tube and a sample plate holder. The sample plate holder includes a device to hold sample plates of different sizes and a device to enable transporting of the sample plate holder by the scintillation counter. For preventing light passage between sample wells in the permeable bottom sheet a light permeable adhesive foil provided with black lines or other light passage preventing treatment between the sample wells is attached to the bottom side of the sample plate.

Abstract: An arrangement for counting liquid scintillation samples on a sample plate in a liquid scintillation counter having at least one photomultiplier tube. The sample plate contains a plurality of open-bottomed wells sealed with at least one filtration membrane impregnated with a solid meltable scintillator. The arrangement includes a sample plate holder for holding and transporting the sample plate in the liquid scintillation counter. The holder includes a device to hold sample plates of different sizes and a device to enable transportation of the sample plate in the liquid scintillation counter.

Abstract: A method for correcting measuring values when measuring liquid scintillation samples deposited on sample plates by a photodetector which will be affected by scintillation photons from other samples in the plate in addition to the sample being measured. Said correction is done by pre-determining affection of the other samples of the plate as a function of quench level and correcting observed measuring values using this function.

Abstract: The present invention provides a scintillation counter that includes a measuring chamber accommodated to take the sample and viewed by two photodetectors, preferably photomultipliers, that can be operated in coincidence. Associated with the chamber is an additional scintillator, preferably an inorganic crystal scintillator, optically isolated from the chamber by a light-permeable wall and mounted so that the scintillation light generated in the additional scintillator is guided predominantly only to one of the two photodetectors. A comparator is used for registering pulse amplitude disparity between the photodetectors to distinguish low-disparity, sample generated pulses and high-disparity, additional scintillator generated pulses.

Abstract: The counting error due to variations in the counting efficiency as a function of the volume of the sample is corrected. The sample is placed into a sample container which is placed into a vertically positioned cylinder shaped counting chamber. Photomultiplier tubes are disposed on the opposite ends of the counting chamber. At least two of the following spectra are measured in the coincidence counting: the sum spectrum q observed by both of the photomultiplier tubes, the spectrum q(y) observed by the upper photomultiplier tube and the spectrum q(a) observed by the lower photomultiplier tube. The counting error is corrected by the correction coefficient obtained from these spectra.

Abstract: An arrangement for improving the counting of liquid scintillation samples including a plurality of separate sample wells, a plate holder surrounding the sides of each sample well so that each plate holder forms an optically separate compartment for each sample well, at least one photomultiplier tube adjacent each sample well, and a coating of light reflective or light scattering material on the inner surfaces of said plate holders.

Abstract: An apparatus for counting liquid scintillation samples which includes a sample plate containing a plurality of cup-shaped sample wells, a photomultiplier assembly over the tops of said cup-shaped sample wells, a photomultiplier assembly beneath the bottoms of said cup-shaped sample wells and light reflective tubes extending upwardly from said lower photomultiplier assembly and surrounding each cup-shaped sample well.

Abstract: In a method of producing a carrier for a plurality of radioactive samples to be monitored in a liquid scintillation counter,wells are provided in a rigid plate (1) of a photon attenuating material in that holes disposed in a matrix configuration are covered from one side of the plate (1) by a first photon permeable foil (2),sample carrying cut-outs (3) from a sorption sheet on which samples have been deposited are placed in said wallsa scintillation fluid is added to the wells, andthe wells are sealed by a second permeable foil (4) to keep the cut-outs (3) and the scintillation fluid within the respective wells.