Abstract: A system and method for providing compliance predictions for using a respiratory pressure therapy device in a treatment regimen is disclosed. The system includes a respiratory pressure therapy device having a transmitter and an air control device to provide respiratory therapy to a patient. The respiratory pressure therapy device collects operational data and transmits the collected operational data. Demographic data of the patient is collected. A predicted compliance with the treatment regimen is determined based on inputting operational data and demographic data to a machine learning compliance prediction model having a compliance prediction output. The machine learning model is trained from the operational data and demographic data of a population of patients using respiratory pressure therapy devices.